Novel magnolol anti-rhinitis and anti-allergy composition

A honokiol and composition technology, applied in the field of novel honokiol anti-rhinitis and allergy compositions, can solve problems such as the lack of elucidation of the anti-inflammatory action mechanism of glycyrrhizin compounds, and achieve reduction of nasal cavity diseases and related complications, Rich Source, Prescription Gentle Effect

Inactive Publication Date: 2016-10-05
佛山市康伲爱伦生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese patents (publication number CN101396368 A) and (publication number CN1965844 A) both use glycyrrhizic acid and isoglycyrrhizic acid d

Method used

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  • Novel magnolol anti-rhinitis and anti-allergy composition
  • Novel magnolol anti-rhinitis and anti-allergy composition
  • Novel magnolol anti-rhinitis and anti-allergy composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A novel magnolol anti-rhinitis and allergy composition consists of the following components and weight ratios:

[0024]

[0025] The rest is water.

[0026] Preparation method and steps of a novel magnolol anti-rhinitis and allergy composition:

[0027] (1) Preparation of magnolol inclusion compound: using HP-β-CD as the inclusion auxiliary material, weighing the raw material with magnolol at a weight ratio of 9:1, using absolute ethanol as the solvent, and preparing thick Puerol inclusion compound.

[0028] (2) Preparation of magnolia flower extract: using distilled water as solvent, extracting at a solid-to-liquid ratio of 1:30, extraction temperature at 80°C, and extraction time for 1 h.

[0029] (3) Weigh raw materials according to prescription and composition weight ratio.

[0030] (4) Add the magnolol inclusion compound and magnolia flower extract prepared in step (1)(2), then add the raw materials weighed in step (3), add water to make the volume to 240mL, ad...

Embodiment 2

[0033] A novel magnolol anti-rhinitis and allergy composition consists of the following components and weight ratios:

[0034]

[0035] The rest is water.

[0036] Preparation method and steps of a novel magnolol anti-rhinitis and allergy composition:

[0037] (1) Preparation of magnolol inclusion compound: using HP-β-CD as the inclusion auxiliary material, weighing the raw material with magnolol in a weight ratio of 3:1, using absolute ethanol as the solvent, and preparing thick Puerol inclusion compound.

[0038] (2) Preparation of magnolia flower extract: Distilled water was used as solvent, and the solid-to-liquid ratio was 1:20 when preparing the extract, the extraction temperature was 100° C., and the extraction time was 0.5 h.

[0039] (3) Weigh raw materials according to prescription and composition weight ratio.

[0040] (4) Add the magnolol inclusion compound and magnolia flower extract prepared in step (1)(2), then add the raw materials weighed in step (3), ad...

Embodiment 3

[0043] A novel magnolol anti-rhinitis and allergy composition consists of the following components and weight ratios:

[0044]

[0045] The rest is water.

[0046] Preparation method and steps of a novel magnolol anti-rhinitis and allergy composition:

[0047] (1) Preparation of magnolol inclusion compound: use β-CD as the inclusion auxiliary material, weigh the raw material with magnolol in a weight ratio of 6:1, use absolute ethanol as the solvent, and prepare magnolol by solvent method clathrate.

[0048] (2) Preparation of magnolia flower extract: Distilled water was used as the solvent, and the solid-to-liquid ratio was 1:10 when preparing the extract, the extraction temperature was 100° C., and the extraction time was 0.8 h.

[0049] (3) Weigh raw materials according to prescription and composition weight ratio.

[0050] (4) Add the magnolol inclusion compound and magnolia flower extract prepared in step (1) (2), then add the raw materials weighed in step (3), add ...

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Abstract

The invention provides a novel magnolol anti-rhinitis and anti-allergy composition. According to the composition, a magnolol inclusion compound is taken as a major anti-inflammatory, anti-allergy, astringent, mucosa-protective and antibacterial ingredient, a flos magnoliae extract and dipotassium glycyrrhizinate are added as a compound anti-inflammatory ingredient, and meanwhile, sea salt and a pH regulating agent are added. All adopted anti-inflammatory active ingredients, which are naturally extracted from medicinal and dietary plants, are rich in source, excellent in such pharmacological actions as resisting bacteria, diminishing inflammation and the like, and are free from any toxic and side effects, cytotoxicity, skin mucosa irritation and the like to human body. The composition can be used for fully clearing bacteria, inhaled particulate dust, harmful materials and the like in nasal cavities and keeping the internal environments of the nasal cavities wet, and the composition is applicable to various people. The composition can be applied in administration modes of nasal drops, a spray and a lotion when the composition is thinned in three forms, namely low osmosis, iso-osmosis and high osmosis differing in concentration; therefore, the composition is beneficial for reducing the occurrence of nasal diseases and related complications, so that an effect on preventing and treating the diseases is achieved.

Description

technical field [0001] The invention relates to a novel magnolol anti-rhinitis and allergy composition with anti-inflammatory, anti-allergic, astringent, mucosal protection and antibacterial properties, which can be used as an anti-inflammatory, anti-allergic and antibacterial component, and can be used for nasal cleaning, antibacterial and anti-rinitis and allergy prevention. Background technique [0002] With the continuous development of industrialization, factory exhaust gas and vehicle exhaust emissions are increasing day by day, and the environment is increasingly seriously polluted, resulting in severe weather such as smog and haze, and the air quality has continued to decline to the point where it cannot be ignored. The air that human beings breathe every moment is very important to individual health. The quality of air directly affects the health of human respiratory tract and then affects other physiological functions. Breathing is accomplished by the upper and lo...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61P31/04A61P31/02A61P11/02A61P37/08A61K31/704A61K31/05
Inventor 郑希张波王凤马诗经黎永良董宇琴
Owner 佛山市康伲爱伦生物技术有限公司
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