A kind of polyglycolic acid-polycaprolactone film and its preparation method and use

Abstract

The invention discloses a polyglycolic acid-polycaprolactone film, which consists of 5-15 parts of polyglycolic acid and 85-95 parts of polycaprolactone in parts by weight; 10 to 200 μm particles, the molecular weight of the polyglycolic acid is 9 to 110,000, the molecular weight of the polycaprolactone is 100,000 to 200,000, and the thickness of the polyglycolic acid-polycaprolactone film is 10 ~ 200 μm; the polyglycolic acid-polycaprolactone film of the present invention is a non-porous dense film in the early stage of implantation, which can isolate the postoperative tissue. Because polyglycolic acid has a faster degradation rate than polycaprolactone, it Micropores can be obtained with the degradation of polyglycolic acid after being implanted into the human body. On the one hand, the appearance of micropores accelerates the breaking and degradation of the material. On the other hand, the film after the appearance of micropores can still maintain the original shape, ensuring The effective isolation function of the film shortens the retention time of the film in the human body and reduces the risk of complications; the preparation method of the polyglycolic acid-polycaprolactone film of the present invention has fewer steps and fewer processes, and is easy to realize industrial production.

Description

technical field [0001] The invention relates to the technical field of films for preventing postoperative tissue adhesion, in particular to a polyglycolic acid-polycaprolactone film and its preparation method and application. Background technique [0002] At present, the polymer materials used to prevent postoperative tissue adhesion in surgical operations generally need to have excellent biocompatibility and biodegradability, such as polylactic acid, polyglycolic acid, polydioxanone, polyhexanone, etc. Lactone, polytrimethylene carbonate, etc., especially polycaprolactone, have good biocompatibility in the body, cells can also grow normally on its skeleton, and can be degraded into carbon dioxide and water, leaving no residue in the body. And it can be molded at low temperature, but the degradation rate of the single polycaprolactone material is slow, and it takes more than 12 to 24 months in the body to degrade completely. The initial strength is high and the mechanical st...

AI Technical Summary

Problems solved by technology

[0002] At present, the polymer materials used to prevent postoperative tissue adhesion in surgical operations generally need to have excellent biocompatibility and biodegradability, such as polylactic acid, polyglycolic acid, polydioxanone, polyhexanone, etc. Lactone, polytrimethylene carbonate, etc., especially polycaprolactone, have good biocompatibility in the body, cells can also grow normally on its skeleton, and can be degraded into carbon dioxide and water, leaving no residue in the body. And it can be molded at low temperature, but the degradation rate of the single polycaprolactone material is slow, and it takes more than 12 to 24 months in the body to degrade completely. The initial strength is high and the mechanical strength lasts for a long time. Although it can ensure the effective isolation of adhesion tissues, Breaks down too slowly, risking complications after surgery