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Application of extract of tamarind shell in the preparation of blood lipid-lowering medicine

An extract and blood lipid-lowering technology, which is applied in the field of plant extracts and its preparation, can solve problems such as high calorie, obesity, and elevated blood lipids, and achieve the effects of low calorie, lower blood lipids, and reduce decomposition

Active Publication Date: 2019-04-16
SINOPHARM GUANGDONG GLOBAL PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tamarind pulp contains a lot of fructose and sucrose, which is high in calories, which can also cause obesity and elevated blood lipids to a certain extent

Method used

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  • Application of extract of tamarind shell in the preparation of blood lipid-lowering medicine
  • Application of extract of tamarind shell in the preparation of blood lipid-lowering medicine
  • Application of extract of tamarind shell in the preparation of blood lipid-lowering medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment one: the preparation of tamarind shell ethanol extract

[0017] Accurately weigh 500g of dry tamarind shells, reclaim the finely powdered tamarind shells after crushing with a pulverizer, add 10 times the amount of 50v / v% hydrous ethanol, heat and reflux for extraction for 120 minutes, and the extract is filtered through gauze, and the filter cake Extract once again under the same conditions, then filter through gauze, and combine the two extracts and filtrates. The solvent is recovered from the filtrate to obtain the extract of the tamarind shell ethanol extract.

Embodiment 2

[0018] Embodiment two: the preparation of tamarind shell water extract

[0019] Accurately weigh 500 g of dried tamarind shells, crush them with a pulverizer, and reclaim the finely powdered tamarind shells, add 5 times the amount of purified water, heat and reflux for extraction for 120 minutes, and filter the extract with gauze, then use the same conditions for the filter cake Extract once, then filter through gauze, and combine the two extract filtrates. After the filtrate is concentrated, it is freeze-dried to obtain the extract of the tamarind shell water extract.

Embodiment 3

[0020] Embodiment three: the chemical composition analysis of tamarind shell extract

[0021] Get 240 mg of the ethanol extract extract of Tamarinosa made in Example 1, dissolve it in 5% methanol, and analyze its chemical composition by liquid chromatography-mass spectrometry (LC-MS), wherein the liquid chromatography column adopts Cosmosil 5 C18-MS-II chromatographic column (4.6ID×250mm, purchased from Hanjing Company, Japan), and the mobile phase was methanol-water (0.2% HCl). After analysis, it was found that the extract of tamarind shell contains a large amount of flavonoids, including quercetin, kaempferol, morin, apigenin, naringenin and luteolin.

[0022] Get the tamarind shell water extract extract prepared in Example 2, and analyze its chemical composition according to the above-mentioned method. After analysis, it was found that the water extract of tamarind shell also contains a large amount of flavonoid active compounds, including quercetin, kaempferol, morin, api...

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Abstract

The invention discloses a tamarindus indica linn. shell extract product and its preparation method and application. The tamarindus indica linn. shell extract product contains ingredients such as quercetin, kaempferol, morin, apigenin, naringenin and luteolin, etc., and can inhibit activity of lipase, reduce blood lipid level, reduce weight and effectively prevent, mitigate and treat hyperlipidemia caused by obesity and complications.

Description

technical field [0001] The invention relates to a plant extract and its preparation method and application, in particular to a tamarind shell extract and its preparation method and application. Background technique [0002] In recent years, with the enrichment of material life, people's fat level is also increasing year by year. Excessive fat intake is considered to be one of the causes of the increase in lifestyle-related diseases such as obesity, hyperlipidemia, arteriosclerosis, and diabetes. Although obesity is affected by many factors such as genetic factors, dietary factors, living habit factors, mental factors, central factors, metabolic factors, and lack of exercise, for most obese people, the accumulation of energy in the body caused by excessive nutritional intake is the key factor. One of its main reasons. According to epidemiological investigations, compared with normal people, most obese people have abnormal tissue fat accumulation. In addition, hyperlipidemi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K36/48A61P3/06A61P3/04A23L33/105
CPCA23V2002/00A61K36/48A61K2236/331A61K2236/333A23V2250/21A23V2200/3262A23V2200/332
Inventor 李维熙王文静苏薇薇栗原博袁春平郭静高永坚
Owner SINOPHARM GUANGDONG GLOBAL PHARMA CO LTD
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