Nutritional composition for use in reducing metabolic stress in infants, decreasing gut permeability and approximating growth rate of breast-fed infants

A nutritional composition, growth rate technology, applied in the field of infant formula products

Inactive Publication Date: 2016-08-24
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] Furthermore, the price of such beneficial means should be reasonable and affordable to most people

Method used

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  • Nutritional composition for use in reducing metabolic stress in infants, decreasing gut permeability and approximating growth rate of breast-fed infants
  • Nutritional composition for use in reducing metabolic stress in infants, decreasing gut permeability and approximating growth rate of breast-fed infants
  • Nutritional composition for use in reducing metabolic stress in infants, decreasing gut permeability and approximating growth rate of breast-fed infants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] Table 1 below gives an example of the composition of an infant formula comprising the oligosaccharide mixture according to the invention. The oligosaccharide mixture comprises 0.1% by weight to 4.0% by weight of (one or more) N-acetylated oligosaccharides, 92.0% by weight to 98.5% by weight of (one or more) galacto-oligosaccharides and 0.3% by weight % to 4.0% by weight of sialylated oligosaccharide(s).

[0131] surface 1 :

[0132]

[0133]

Embodiment 2

[0135] This example shows that the nutritional composition as shown in Example 1 is effective in reducing metabolic stress ( figure 1 and Table 2), reduced intestinal permeability ( figure 2 and Table 3) and increase the growth rate of infants fed with the nutritional composition ( image 3 with Figure 4 ) aspects of the effect.

[0136] 2.1 experimental design

[0137] This is a multicentre, parallel group, double-blind, randomized controlled trial. A total of 202 healthy term neonates were selected from mothers enrolled in the Perinatal Care Research Center. Infants from mothers who chose not to breastfeed for more than 48 hours after birth were included in the formula group, while a reference group of breastfed (BF) infants came from mothers who wanted to breastfeed their infants for at least 4 months from birth.

[0138] Infants from random size (within 48 hours of birth) to 1 month of age are provided with standard infant formula (FF) or the same standard infant...

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PUM

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Abstract

The present invention relates to a nutritional composition comprising an oligosaccharide mixture, said oligosaccharide mixture comprising at least one N- acetylated oligosaccharide, one galacto-oligosaccharide and one sialylated oligosaccharide for use in reducing the metabolic stress in an infant in the first twelve months of life and / or decreasing gut permeability in an infant in the first twelve months of life and / or promoting a rate of growth in an infant fed with said nutritional composition in the first twelve months of life which approximates to the rate of growth of a breast-fed infant at the same age.

Description

technical field [0001] The present invention relates to a nutritional composition, such as an infant formula, comprising a mixture of oligosaccharides specially designed to reduce metabolic stress, lower intestinal channel permeability and increased growth rate. Background technique [0002] The human colon is colonized by a wide variety of bacteria that have beneficial or deleterious effects on gut physiology, as well as other systemic effects. Predominant groups of bacteria found in the colon include Bacteroides, Bifidobacteria, Eubacteria, Clostridium, and Lactobacilli. The bacteria present have fluctuating activity in response to substrate availability, redox potential, pH, oxygen tension and oxygen distribution within the colon. Pathogenic effects (eg, possibly caused by Clostridium or Bacteroides) include diarrhea, infection, liver injury, carcinogenesis, and intestinal putrefaction. Health-promoting effects can be achieved by inhibiting the growth and colonization ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L29/30A23L33/00A23L33/135
CPCA23V2002/00A23V2400/147A23V2400/143A23V2400/151A23V2400/125A23V2400/123A23V2400/113A23V2400/181A23V2400/215A23V2400/219A23V2400/245A23V2400/175A23V2400/231A23V2400/169A23V2400/513A23V2400/515A23V2400/249A23V2400/519A23V2400/529A23V2400/531A23V2400/533A23V2200/32A23V2200/3204A23V2250/282A23V2250/606A23V2250/5062A23V2250/638A23V2250/608A61K35/20A23L29/30A23L33/40A23L33/10A23L33/135A23L33/21A23L5/00A61K31/702A61K2300/00A23V2200/3202A23V2250/28A61K9/0053A61K35/741A61K2035/115
Inventor J·本雅各布N·德 格鲁特P·斯滕豪特
Owner SOC DES PROD NESTLE SA
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