Device for establishing mouse hepatic cancer orthotopic transplantation tumor model

Abstract

The invention relates to a device for establishing a mouse hepatic cancer orthotopic transplantation tumor model, this device being accurate to position and practical and convenient to use during injection to a liver of a mouse. The device comprises a positioning plate A and a positioning plate B, the positioning plate A includes a front plane A, a rear plane and a right plate, a groove A is connected between the front plane A and the rear plane, and the front face of the groove A is provided with an injecting hole; the positioning plate B comprises a front plane B, a rear bevel and a left plate, a groove B is connected between the front plane B and the rear bevel, and the front face of the groove B is provided with an injecting hole; the positioning plate A and the positioning plate B are connected through groove inserting to form an injection positioning plate, and after inserting, the positioning plate B is positioned above the positioning plate A. The injection positioning plate is accurate to position and easy to operate, reproducibility of experiments is guaranteed, model success rate is further increased, and the device is applicable to experimental operations in various prevention and treatment studies on various liver cancer, such as establishment of animal models and mouse liver orthotopic injection.

Description

technical field [0001] The invention relates to a device for establishing an animal model of orthotopic transplanted tumor of mouse liver cancer, in particular to an injection positioning device for injection operation in the mouse liver. Background technique [0002] In order to carry out research on tumor prevention and treatment, scientists need to establish a variety of tumor animal models and apply them in the etiology, pathogenesis and treatment of tumors. There are many ways to establish tumor animal models, but the most commonly used one is the tumor transplantation model. Among various animal models of tumor transplantation, the animal model of subcutaneous tumor transplantation in mice is the most used, which has the advantages of simple operation, high tumor formation rate, and economical and practical advantages. The disadvantage of subcutaneous xenografts is that they are quite different from the corresponding primary tumors. Therefore, in some special researc...

AI Technical Summary

Problems solved by technology

[0003] The establishment process of the traditional orthotopic tumor transplantation animal model is relatively complicated, and most of them need to implant tumor tissue or cells into the corresponding organs through surgery, so that they can form tumors in the corresponding organs.

The establishment of each animal model needs to go through complex processes such as anesthetizing the animal, removing the coat, incision of the skin, implanting the tumor, suturing the wound, and waking up the animal. material, which is difficult to complete when the sample size is large

At the same time, due to the greater damage to the animals during the operation, the animals need to recover after a certain period of time, which will also have a certain impact on the experimental research work.

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