Polysaccharide styptic powder, preparation method and applications thereof

Abstract

The invention relates to polysaccharide styptic powder, a preparation method and applications thereof. Plant origin starch and etherified starch are taken as the raw materials, two starches are individually processed by ultrasonic waves, then two starches are emulsified and crosslinked, and finally the crosslinking product is subjected to extraction, liquid separation, washing, drying, and sterilization to obtain the styptic powder. The styptic powder has a good biocompatibility, can be directly applied to the common bleeding parts, deep bleeding parts, and bleeding parts that are hard to reach through surgery operation, and is simple and convenient to use. Starches are the raw materials of the styptic powder, thus the styptic powder is nontoxic and nonirritant, moreover, the sources of raw materials are wide, the cost is low, the technology is simple and feasible, and thus the styptic powder has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a polysaccharide hemostatic powder and a preparation method and application thereof. Background technique [0002] Bleeding is one of the problems that need to be solved urgently in surgery. The normal human body has the function of hemostasis. Slow and small amount of bleeding can be stopped by its own function. The body cannot stop the bleeding by itself, nor can it only be stopped by ordinary hemostatic bandages. Excessive bleeding during the operation will prolong the operation time, and serious complications will occur, such as hemorrhagic shock, which may even endanger life and health. Currently, the commonly used effective hemostasis method is to use biocompatible absorbable materials to stop bleeding. It is particularly important to provide a safe, effective, easy-to-use, and low-cost hemostatic material in hemostasis such as surgery and first aid. [0003...

AI Technical Summary

Problems solved by technology

[0003] At present, the clinically used hemostatic materials mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials. These materials have achieved good results in animal experiments and clinical applications, but there are also some shortcomings: The raw material is derived from animal tissue, which is a foreign protein, which is prone to rejection and has potential sensitization; gelatin absorbs slowly, generally more than 4 weeks, which will increase the risk of wound infection; cellulose, the human body lacks enzymes to degrade it , the degradation time is long, which may bring side effects such as infection to the patient

At present, the representative starch hemostatic material is Arista hemostatic powder produced in the United States. Although its hemostatic effect is good, it is cross-linked with epichlorohydrin, which is potentially toxic and expensive, which limits its application.