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Preparation method for artificial bone scaffold capable of loading drugs according to layers and quantity

An artificial bone and drug-loaded technology, applied in the field of medical artificial bone graft materials, to achieve the effects of avoiding secondary infection, relieving pain, and high value-added rate

Inactive Publication Date: 2016-07-13
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the use of drug-loaded calcium phosphate bone cement to prepare drug-loaded artificial bone scaffolds through a biological three-dimensional extrusion molding machine. At the same time, according to the needs of patients, multiple drugs are loaded, and the amount of each drug can be adjusted according to the needs of patients. It can be added on demand, and the effect of hierarchical release can be achieved through the different order of drug embedding.

Method used

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Examples

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Embodiment Construction

[0042] Embodiments of the present invention are described in detail below, and the embodiments are exemplary and intended to explain the present invention, but should not be construed as limiting the present invention.

[0043] The preparation method of the layered component drug-loaded artificial bone scaffold in the embodiment comprises the following steps:

[0044] Step 1: According to the concentration requirements of the artificial bone scaffold for post-release drugs, configure several calcium phosphate dihydrate mixed powders containing different mass fractions of post-release drugs; the calcium phosphate dihydrate mixed powders are composed of calcium phosphate dihydrate powder and post-release drugs. Medication powders are mixed.

[0045] The post-release drug in this example is Rhizoma Drynariae. According to the concentration requirements of artificial bone scaffolds for post-release drugs, dihydrate containing Drynaria rhizome with mass fractions of 3%, 5%, and 8% ...

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Abstract

The invention provides a preparation method for an artificial bone scaffold capable of loading drugs according to layers and quantity.The method comprises the steps that a rapid molding method through a biological three-dimensional extrusion molding machine is adopted, different drugs and calcium phosphate cement are mixed and embedded, an artificial bone scaffold three-dimensional CAD model is processed by means of a computer, bio-adhesive and mixed powder are mixed to be uniform to be put into the biological three-dimensional extrusion molding machine, and a bone scaffold mold which accords with bone porosity of an individual patient, has the anti-infection characteristic and is good in biocompatibility is obtained through extrusion molding.According to the preparation method for the artificial bone scaffold, the different drugs can be selectively sprayed on the specific portions of an artificial bone according to needs of the patients; by means of the arrangement of different gradients for different drugs, various drugs with different contents can be loaded on different portions of the same drug-loading artificial bone scaffold, and complex local drug combined application is formed.

Description

technical field [0001] The invention relates to the technical field of medical artificial bone graft materials, in particular to a method for preparing layered component artificial bone brackets through calcium phosphate bone cement loaded with various drugs. Background technique [0002] In the field of orthopedics, bone defects due to severe trauma, bone tumors, osteomyelitis and other reasons are very common. Currently commonly used bone repair materials include autologous bone and allogeneic bone. The source of autologous bone is limited, and there are many postoperative complications, which increase the trauma and pain of the patient; the exogenous bone will cause rejection of the body, and there are problems such as loosening and fracture, and the success rate of transplantation is low. In the process of repairing traumatic bone damage, it is very easy to cause infection. Whether the replacement bone graft is successful or not is closely related to whether it is infec...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/54A61L27/56A61L27/58
CPCA61L27/12A61L27/54A61L27/56A61L27/58A61L2300/23A61L2300/30A61L2300/406A61L2300/602
Inventor 汪焰恩车煜魏庆华李欣培杨明明柴卫红卢婷利赵雯
Owner NORTHWESTERN POLYTECHNICAL UNIV
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