Treatment of ventricular arrhythmias through combination of potassium aspartate and amiodarone

A technology for ventricular arrhythmia and potassium aspartate, which can be used in drug combinations, cardiovascular system diseases, etc., and can solve problems such as not inhibiting left ventricular function.

Inactive Publication Date: 2016-06-29
LIAONING YAOLIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Intravenous injection has mildly negative inotropic effects, but usually does not depress LV function

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment

[0005] All 65 cases met the WHO diagnostic criteria for coronary heart disease. There were 39 males and 26 females; the age ranged from 38 to 65 years, with an average of 52.1 years; the disease duration was 0.4 to 2.8 years, with an average of 1.5 years. They were randomly divided into two groups, 33 cases in the treatment group and 32 cases in the control group. There was no significant difference in gender, age, course of disease, and severity of VA between the two groups, and they were comparable.

[0006] Treatment methods: All patients were treated with nitrates and other conventional treatments, and the control group was treated with amiodarone alone; the treatment group was treated with potassium aspartate (Liaoning Yaolian Pharmaceutical Co., Ltd.) on the basis of the control group. Production, correspondingly containing K + 114 × 4 mg, Mg2 + 4.2 × 4 mg) 40 mL was added to 5% glucose solution or normal saline for intravenous drip, once a day, 3 weeks as a course of tr...

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PUM

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Abstract

Potassium aspartate combined with amiodarone was used to treat ventricular arrhythmia in coronary heart disease, and the curative effect was satisfactory.

Description

technical field [0001] The invention relates to a potassium supplement injection for treating ventricular arrhythmia, in particular to a method for treating ventricular arrhythmia by injecting active ingredients potassium salt and amiodarone into the body, and belongs to the field of pharmaceutical preparations . Background technique [0002] It is a class III antiarrhythmic drug. A mildly noncompetitive alpha and beta adrenergic blocker. And with mild class I and IV antiarrhythmic properties. The main electrophysiological effect is to prolong the action potential and effective refractory period of various myocardial tissues, which is beneficial to eliminate the reentrant excitation. Inhibits the rapid influx of sodium ions in the conduction fibers of the atrium and myocardium, and slows down the conduction velocity. Decreases sinoatrial node self-discipline. No effect on resting membrane potential and action potential height. The inhibition of forward conduction of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P9/06A61K31/198
Inventor 于航李重琦
Owner LIAONING YAOLIAN PHARMA
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