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A noninvasive dynamic muscle oxygen uptake rate measuring method based on magnetic resonance imaging

A magnetic resonance imaging, oxygen uptake rate technology, applied in the field of muscle oxygen uptake rate change map

Inactive Publication Date: 2016-06-22
PEKING UNIV
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Problems solved by technology

However, there are some defects in their method, for example, two independent scans are used to obtain T2 and T2* in the process of obtaining R2', which will lead to various physiological changes and motions between measurements in the process of calculating R2' On the other hand, Elder et al. only obtained the average value of %HbO2 of a local muscle tissue, but obtained the oxygen uptake rate of the whole muscle (1-%HbO2 2 ) map information is often more needed

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  • A noninvasive dynamic muscle oxygen uptake rate measuring method based on magnetic resonance imaging
  • A noninvasive dynamic muscle oxygen uptake rate measuring method based on magnetic resonance imaging
  • A noninvasive dynamic muscle oxygen uptake rate measuring method based on magnetic resonance imaging

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Embodiment Construction

[0015] The calf muscles of the lower extremities are taken as an example. During the MRI process, the subject lies on his back on the MR scanning bed, an inflatable blood pressure belt is tied to the thigh of the right leg, and a nylon belt is used to fix the blood pressure belt to prevent the blood pressure belt from loosening. During the scan, keep the subject's head, feet, and knees at the same level. The psMASE sequence scan should be performed after the routine positioning scan and reference image scan. A suitable psMASE sequence parameter can be set as follows: fieldofview(FOV)=150×150mm 2 ,matrixsize=70×70,repetitiontime(TR)=2000ms,TE 1 / TE 2 / TE 3 / TE 4 =60 / 80 / 100 / 120ms, echospace=20ms, τ=-10 / 0 / 10ms, slicethickness=6mm, SENSEfactor=2, NSA=1, echoshiftnumber=12. The subject remained in a resting state for 10 minutes, and then we manually inflated the blood pressure belt to a pressure of 200mmHg. The entire inflation process was completed within 5 seconds and maintai...

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Abstract

The invention provides a method of estimating the distribution diagram of the dynamic oxygen uptake rates of whole muscular tissue by using the imaging results of noninvasive quantitative dynamic magnetic resonance R2' and the results of the oxygen uptake rates of superficial muscle tissue measured by an NIRS. The method comprises the step of firstly, dynamically obtaining the R2' distribution diagram of the whole muscle tissue according to an improved multiple-echo asymmetrical spin echo (ps MASE) sequence of pulses periodically moving for 180 degrees and a moving window estimation (ME) strategy; secondly, obtaining the %HbO2 change curve of superficial muscles by using the NIRS and performing sampling to the time resolution the same as that of dynamic R2' measurement; thirdly, fitting the R2' and the %HbO2 via a secondary empirical equation and calculating the dynamic 1-%HbO2 change process of the whole diagram via a coefficient obtained after fitting.

Description

technical field [0001] The invention belongs to the technical field of functional magnetic resonance imaging, and specifically relates to a transient ischemia model of lower limbs and magnetic resonance dynamic R2' measurement technology, and uses an empirical relationship to calibrate the R2' dynamic curve to obtain the change of muscle oxygen uptake rate non-invasively and dynamically Figure method. Background technique [0002] Noninvasive measurement of oxygen consumption and metabolism of skeletal muscle has very important applications in many fields. An accurate, repeatable and non-invasive technique for quantifying skeletal muscle oxygen consumption is the focus of scientific research and clinical workers, and will play a very important role in the research and diagnosis of muscle pathology and physiological functions. [0003] Currently, many imaging modalities have been used to quantify muscle oxygen consumption. In general, the transcutaneous partial pressure of ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055
Inventor 王成彦张锐王鹤金立新王霄英张珏方竞
Owner PEKING UNIV
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