Applications of fucoidan in preparation of drugs for prevention and treatment of male reproductive toxicity caused by organophosphorus pesticide

Abstract

The present invention relates to a new pharmaceutical use of fucoidan, ie., prevention and treatment of male reproductive toxicity caused by organophosphorus pesticide, further to applications of the fucoidan in preparation of drugs for inhibition of sperm motility decreasing, abnormal sperm increasing, testis tissue MDA content increasing, testis tissue CAT activity decreasing and testis tissue LDH activity decreasing caused by organophosphorus pesticide. According to the present invention, the high-toxicity organophosphorus pesticide monocrotophos and the low-toxicity organophosphorus pesticide phoxim are adopted as the representatives to research the prevention and treatment effect of the fucoidan on male reproductive toxicity caused by the low-concentration organophosphorus pesticide, such that it is proved that the fucoidan can inhibit the male reproductive toxicity caused by the organophosphorus pesticide, and has a good dose-dependent manner so as to provide the applications of the fucoidan as the active substance in preparation of the drugs for prevention and control of male reproductive toxicity caused by the organophosphorus pesticide.

Description

technical field [0001] The invention relates to the application of fucoidan, in particular to the application of fucoidan in the preparation of medicines for preventing and treating male reproductive toxicity diseases caused by organophosphorus pesticides. Background technique [0002] Organophosphorus pesticides (OPs) are a class of high-efficiency, low-residue pesticides that have become the broadest-spectrum pesticides used in China today. The use of organophosphorus pesticides has made great contributions to the increase of production and harvest in agriculture, forestry, and fishery. However, with the widespread use of organophosphorus pesticides, their residues in vegetables and fruits are also more common. Although most people have paid attention to the prevention of acute poisoning of organophosphorus pesticides, the impact of long-term, low-dose, and chronic exposure of organophosphorus pesticides on human health, especially on male fertility, has not attracted enou...

AI Technical Summary

Problems solved by technology

Although most people have paid attention to the prevention of acute poisoning of organophosphorus pesticides, the impact of long-term, low-

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