Medicine-carrying aquogel coating and preparation method and application thereof
An alumina hydrogel and gel technology, applied in coating, medical science, tissue regeneration, etc., can solve the problems of delayed infection and unsatisfactory bacteriostatic effect, and achieve the effect of preventing delayed infection
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Embodiment 1
[0043] In this embodiment, the drug-loaded hydrogel coating is prepared by the following method, which specifically includes the following steps:
[0044] (1) Add 2.5g of aluminum isopropoxide into 50mL of deionized water, stir the white precipitate at 80°C for 15min to obtain a dispersion, ultrasonically treat the dispersion for 2h, and cool to room temperature to obtain an alumina hydrogel (Al 2 o 3 ·H 2 O), wherein the mass content of aluminum is 2%.
[0045] (2) Dissolve 10 mg of the anti-infective drug penicillin in 1 mL of Tris-hydrochloric acid buffer (concentration 0.05 M) at pH=7.4 to obtain an anti-infective drug solution, and mix 100 μL of the alumina hydrogel obtained in step (1) with 50 μL of the anti-infective drug Mix the solution in a 1.5mL glass tube evenly, then use a pipette gun to take 50μL of the mixed solution on a glass slide (2cm×2cm in size), use a Meyer rod to repeatedly press and coat 5 times to coat evenly, and then put it in a vacuum drying oven ...
Embodiment 2
[0047] In this embodiment, the drug-loaded hydrogel coating is prepared by the following method, which specifically includes the following steps:
[0048] (1) Add 2.5g of aluminum isopropoxide into 25mL of deionized water, stir the white precipitate at 80°C for 30min to obtain a dispersion, ultrasonically treat the dispersion for 1h, and cool to room temperature to obtain an alumina hydrogel (Al 2 o 3 ·H 2 O), wherein the mass content of aluminum is 3%.
[0049] (2) 10 mg of anti-infective drug erythromycin was dissolved in 2 mL of Tris-hydrochloric acid buffer (concentration 0.05 M) at pH=7.4 to obtain an anti-infective drug solution, and 100 μL of alumina hydrogel obtained in step (1) was mixed with 80 μL of anti-infective drug Mix the infection drug solution in a 1.5mL glass tube evenly, then use a pipette gun to take 50μL of the mixed solution on a glass slide (2cm×2cm in size), use a Meyer rod to repeatedly press 7 times to coat evenly, and then put it in a vacuum Dry ...
Embodiment 3
[0051] In this embodiment, the drug-loaded hydrogel coating is prepared by the following method, which specifically includes the following steps:
[0052] (1) Add 2.5g of aluminum isopropoxide into 75mL of deionized water, stir the white precipitate at 80°C for 20min to obtain a dispersion, ultrasonicate the dispersion for 3h, cool to room temperature, and obtain an alumina hydrogel (Al 2 o 3 ·H 2 O), wherein the mass content of aluminum is 1%.
[0053] (2) Dissolve 10 mg of the anti-infective drug levofloxacin in 3 mL of Tris-hydrochloride buffer (concentration 0.05 M) at pH=7.4 to obtain an anti-infective drug solution, and mix 100 μL of the alumina hydrogel obtained in step (1) with 30 μL of the anti-infective drug Mix the solution in a 1.5mL glass tube evenly, then use a pipette gun to take 50μL of the mixed solution on a glass slide (2cm×2cm in size), use a Meyer rod to repeatedly press and coat 3 times to coat evenly, and then put it in a vacuum drying oven Dry at med...
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