A kind of drug-loaded hydrogel coating and preparation method and application thereof
A kind of aluminum oxide hydrogel and gel technology, applied in coating, medical science, tissue regeneration, etc., can solve the problems of delayed infection and unsatisfactory antibacterial effect, and achieve the effect of preventing delayed infection
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0043] In this embodiment, the preparation of the drug-loaded hydrogel coating by the following method specifically includes the following steps:
[0044] (1) Add 2.5 g of aluminum isopropoxide to 50 mL of deionized water, and stir the white precipitate at 80°C for 15 minutes to obtain a dispersion. The dispersion is ultrasonically treated for 2 hours and cooled to room temperature to obtain alumina hydrogel (Al 2 O 3 ·H 2 O), where the mass content of aluminum is 2%.
[0045] (2) Dissolve 10 mg of anti-infective penicillin in 1 mL of Tris-hydrochloric acid buffer (concentration 0.05M) with pH=7.4 to obtain an anti-infective solution, and combine 100 μL of the alumina hydrogel obtained in step (1) with 50 μL of anti-infection The drug solution was mixed uniformly in a 1.5mL glass tube, and then 50μL of the mixed solution was taken on a glass slide (2cm×2cm size) with a pipette, and the Meyer rod was used to repeatedly press and coat it for 5 times, and then put it in a vacuum to dry...
Embodiment 2
[0047] In this embodiment, the preparation of the drug-loaded hydrogel coating by the following method specifically includes the following steps:
[0048] (1) Add 2.5g of aluminum isopropoxide to 25mL of deionized water, stir the white precipitate at 80°C for 30min to obtain a dispersion, then ultrasonically treat the dispersion for 1h and cool to room temperature to obtain an alumina hydrogel (Al 2 O 3 ·H 2 O), where the mass content of aluminum is 3%.
[0049] (2) Dissolve 10 mg of the anti-infective drug erythromycin in 2 mL of pH=7.4 Tris-hydrochloric acid buffer (concentration 0.05M) to obtain an anti-infective drug solution, and mix 100 μL of the alumina hydrogel obtained in step (1) with 80 μL The anti-infective drug solution was mixed uniformly in a 1.5mL glass tube, and then 50μL of the mixed solution was taken on a glass slide (2cm×2cm size) with a pipette, and the Meyer rod was used to repeatedly press and apply 7 times to coat it evenly. Drying in a vacuum drying oven a...
Embodiment 3
[0051] In this embodiment, the preparation of the drug-loaded hydrogel coating by the following method specifically includes the following steps:
[0052] (1) Add 2.5g of aluminum isopropoxide to 75mL of deionized water, stir the white precipitate at 80°C for 20min to obtain a dispersion, then ultrasonically treat the dispersion for 3h and cool to room temperature to obtain alumina hydrogel (Al 2 O 3 ·H 2 O), where the mass content of aluminum is 1%.
[0053] (2) Dissolve 10 mg of the anti-infective drug levofloxacin in 3 mL of pH=7.4 Tris-hydrochloric acid buffer (concentration 0.05M) to obtain an anti-infective drug solution, and combine 100 μL of the alumina hydrogel obtained in step (1) with 30 μL of anti-infection The drug solution was mixed uniformly in a 1.5mL glass tube, and then 50μL of the mixed solution was taken on a glass slide (2cm×2cm size) with a pipette, and the Meyer rod was used to repeatedly press and coat it for 3 times, and then place it in a vacuum to dry. Dr...
PUM
Property | Measurement | Unit |
---|---|---|
thickness | aaaaa | aaaaa |
thickness | aaaaa | aaaaa |
thickness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
![application no application](https://static-eureka-patsnap-com.libproxy1.nus.edu.sg/ssr/23.2.0/_nuxt/application.06fe782c.png)
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap