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Traditional Chinese medicine composition for treating bacillary dysentery and preparing method and quality control method thereof

A composition and bacterial technology, applied in antibacterial drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as failure to achieve expected effects, and achieve the effects of convenient administration, good curative effect, and simple raw materials

Inactive Publication Date: 2016-03-16
武汉钧安制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, modern medicine often fails to achieve the desired effect in the treatment of a certain clinical symptom.

Method used

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  • Traditional Chinese medicine composition for treating bacillary dysentery and preparing method and quality control method thereof
  • Traditional Chinese medicine composition for treating bacillary dysentery and preparing method and quality control method thereof
  • Traditional Chinese medicine composition for treating bacillary dysentery and preparing method and quality control method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 Chinese medicine composition

[0021] Andrographis paniculata was soaked and extracted with ethanol, and the four factors of ethanol dosage, ethanol concentration, extraction time, and extraction temperature were investigated. Each factor took three levels, and L9 (34) orthogonal table experiment was selected. The factor levels are shown in the table below. Each experiment accurately weighed 100g Andrographis paniculata powder for extraction, and the filtrate was concentrated into an extract.

[0022] Level A: Ratio of material to liquid B: ethanol concentration / % C: extraction time / h D: Temperature / °C 1 8 50 8 2～8 2 10 75 12 20～25 3 12 95 24 30～35

[0023] Taking the amount of extracted andrographolide as an investigation index, the results are shown in the table below.

[0024]

[0025]

[0026] It can be seen from the orthogonal test table 1-2 that the four factors investigated above ...

Embodiment 2

[0037] Embodiment 2 Chinese medicine composition capsule preparation

[0038] Get 200 g of Andrographis paniculata and add 12 times of ethanol to soak twice, each time for 12 hours, filter, combine the filtrate, reclaim ethanol and concentrate to the extract I of relative density 1.30~1.35 (50 ℃), set aside. Take 200g of bitter wood, 50g of tangerine peel, and 50g of licorice, and grind them into coarse powder, add ethanol 10 times and slowly percolate, recover ethanol from the filtrate, concentrate to extract II with a relative density of 1.30-1.35 (50°C), and set aside. The above two extracts are mixed, dried in vacuum, pulverized, mixed with an appropriate amount of starch, made into a soft material with 60% ethanol, granulated, dried, sized, added with an appropriate amount of magnesium stearate, mixed evenly, packed into capsules, Make 1000 capsules, that is.

Embodiment 3

[0039] Embodiment 3 Chinese medicine composition tablet preparation

[0040] Get 250g Andrographis paniculata and add 12 times of ethanol to soak twice, each time for 12 hours, filter, combine the filtrate, reclaim ethanol and concentrate to the extract I of relative density 1.30~1.35 (50 ℃), set aside. Take 250g of bitter wood, 62.5g of tangerine peel, and 62.5g of licorice and grind them into coarse powder, add 10 times of ethanol and slowly percolate, recover ethanol from the filtrate, concentrate to extract II with a relative density of 1.30-1.35 (50°C), and set aside. The above two kinds of extracts are mixed, dried in vacuum, pulverized, mixed with an appropriate amount of starch, made into a soft material with 60% ethanol, granulated, dried, pressed into tablets, and made into 1000 pieces.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating bacillary dysentery and a preparing method and quality control method thereof. The traditional Chinese medicine composition is prepared from andrographis paniculata, picrasma quassioides, pericarpium citri reticulatae and liquorice. The traditional Chinese medicine composition can clear away heat and toxic materials and eliminate dampness and dysentery, and can be used for treating bacillary dysentery, acute enteritis and various acute infectious diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating bacillary dysentery, a preparation method thereof and a quality control method thereof. Background technique [0002] Bacillary dysentery (bacillary dysentery) is a common acute intestinal infectious disease caused by Shigella, with colon suppurative inflammation as the main lesion, with systemic poisoning symptoms, abdominal pain, diarrhea, tenesmus, and bloody stools. In severe cases, convulsions, coma, and shock may occur. It occurs throughout the year, and is most common in summer and autumn. [0003] The clinical symptoms are different due to the different types of Shigella entering the human body, the number and the resistance of each person, so the symptoms are also different. Therefore, clinically, dysentery is divided into two types: acute and chronic. According to the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P1/12A61P31/04G01N30/88
CPCA61K36/185A61K36/19A61K36/484A61K36/752A61K2236/331A61K2236/333A61K2236/39A61K2236/51G01N30/88G01N2030/884A61K2300/00Y02A50/30
Inventor 李宏伟徐石清童玲玲
Owner 武汉钧安制药有限公司
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