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Solid dispersible granule for treating peptic ulcer

A peptic ulcer and solid dispersion technology, which is applied to the digestive system, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., can solve the problems of high cost, high medicinal taste, and large amount of medicinal materials. Enhanced anti-ulcer activity, good analgesic effect, and improved bioavailability

Inactive Publication Date: 2016-03-09
门源县雪草木生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned prescriptions have more medicinal flavors, a larger amount of medicinal materials, and higher costs

Method used

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  • Solid dispersible granule for treating peptic ulcer
  • Solid dispersible granule for treating peptic ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0028] Zushima 3g, Anisopolamine 0.5g, Dried Ginger 9g, Seabuckthorn 10g; after drying, crush to 300 mesh, mix evenly to get raw material medicine powder.

[0029] Take raw drug powder: polyethylene glycol-6000=1:1w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

[0030] Take the solid dispersion: dextrin = 1:1w / w, use water as the binder, and wet granulate to obtain solid dispersion granules.

Embodiment 2

[0031] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0032] Zushima 1g, Anisopolamine 0.6g, Dried Ginger 6g, Seabuckthorn 10g; after drying, crush to 400 mesh, mix evenly to get the raw material medicine powder.

[0033] Take raw drug powder: polyethylene glycol-6000=1:3w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

[0034] Take solid dispersion: starch=1:3w / w, use starch slurry as binder, wet granulate to obtain solid dispersion granules.

Embodiment 3

[0035] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0036] Zushima 1g, anisopolamine 0.3g, dried ginger 10g, seabuckthorn 6g; after drying, crush into 500 meshes, and mix well to obtain the raw material medicine powder.

[0037] Take raw drug powder: polyethylene glycol-6000=3:1w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, pulverize to obtain Solid dispersion.

[0038] Take solid dispersion: microcrystalline cellulose: dextrin = 1:1:1 w / w, use 70% v / v ethanol as binder, and wet granulate to obtain solid dispersion granules.

[0039] The beneficial effects of the present invention are further demonstrated through specific test examples below.

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Abstract

The invention provides a solid dispersible granule for treating peptic ulcer, which is prepared from 1 part by weight of solid dispersion and 1-3 parts by weight of filling agent, wherein the solid dispersion is prepared from raw medicine powder and polyethylene glycol-6000 in a ratio of (1-3):(1-3) by weight; and the raw medicine powder is prepared by crushing the following raw medicines in parts by weight into 300-500 meshes: 1-3 parts of girald daphne bark, 0.3-0.6 part of anisodus tanguticus, 6-10 parts of dried ginger and 6-10 parts of sea buckthorn. According to the invention, the raw medicine powder is prepared into the solid dispersion, so that the bioavailability of the medicine is increased, and the anti-ulcer activity is obviously increased. However, the solid dispersion is too large in specific surface area, relatively easy in moisture absorption, not suitable for storage and production, not good in flowing property and not convenient for production and packaging. Accordingly, in the invention, the solid dispersion is prepared into the granule so as to be convenient for storage, transportation and packaging and convenient for patients to use.

Description

technical field [0001] The invention relates to a solid dispersion granule for treating peptic ulcer. Background technique [0002] Gastric and duodenal ulcers refer to localized round or oval full-thickness defects of gastric and duodenal mucosa, the muscularis mucosae is penetrated, and fibrous scars inevitably remain after healing, with a layer of epithelium on the surface Overlying, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic erosive gastritis, also known as verrucous gastritis or pimple-like gastritis, generally only sees dyspepsia symptoms such as fullness after meals, pantothenic acid, belching, and irregular abdominal pain. Multiple verruc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/16A61P1/04
CPCA61K36/83A61K9/1641A61K36/185A61K36/81A61K36/9068
Inventor 徐继锋卞海军许婧
Owner 门源县雪草木生物药业有限公司
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