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Application of Ruyizhenbao preparation in preparing medicine for nerve injury protection and regeneration

A technology for nerve damage, medicine, applied in the field of medicine

Inactive Publication Date: 2016-03-09
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the existing technology, the pharmacological effects of Ruyi Zhenbao pills are mainly reflected in promoting blood circulation, anti-inflammation and analgesia, anti-hypoxia, promoting chondrocyte differentiation, as well as macroscopically analgesic and improving stroke sequelae. Reports on Pills' Protection of Nerve Injury and Promotion of Injured Nerve Regeneration

Method used

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  • Application of Ruyizhenbao preparation in preparing medicine for nerve injury protection and regeneration
  • Application of Ruyizhenbao preparation in preparing medicine for nerve injury protection and regeneration
  • Application of Ruyizhenbao preparation in preparing medicine for nerve injury protection and regeneration

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0040] Experimental example 1. Protective and regeneration-promoting effects on zebrafish nerve injury

[0041] 1 Experimental materials

[0042] 1.1 Drugs and reagents

[0043] Ruyi Zhenbao Pills (0.5g / pill, produced by Jinhe Tibetan Medicine Co., Ltd., batch number 20150129), mycophenolate mofetil (Shanghai Jingchun Industrial Co., Ltd., batch number 128794-94-5), reduced glutathione Glycine (Shanghai Jingchun Industrial Co., Ltd., batch number 70-18-8), L-thyroxine sodium T3 / T4 (white powder, Shanghai Jingchun Industrial Co., Ltd., batch number 55-03-8), ethanol (no Color liquid, Hangzhou Longshan Fine Chemical Co., Ltd., batch number is 64-17-5), aspirin (Aladdin, batch number is G1220028).

[0044] 1.2 Instruments

[0045] Dissecting microscope (SZX7, OLYMPUS, Japan); motorized focus zoom fluorescence microscope (AZ100, Nikon); 6-well plate (NestBiotech); methylcellulose (Aladdin, Shanghai, China), behavioral analyzer (V3, ViewPointLifeSciences company).

[0046] 1.3...

Embodiment 1

[0095] Example 1. Application of Ruyi Zhenbao Pills in the Preparation of Drugs for Promoting the Regeneration of Peripheral Motor Nerve Injury

[0096] Usage and dosage: 2-2.5g once, twice a day.

Embodiment 2

[0097] Example 2. Application of Ruyi Zhenbao Pills in the Preparation of Drugs for Promoting Axonal Regeneration of Peripheral Motor Nerves

[0098] Usage and dosage: 2-2.5g once, twice a day.

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Abstract

The invention discloses an application of a Ruyizhenbao preparation in preparing a medicine for nerve injury protection and regeneration, belonging to the field of medicines. According to the conventional practice, Ruyizhenbao pills have the inflammation-resisting and pain-easing effects for the nervous system. To correct the technical bias, it is found that the Ruyizhenbao pills have a significant protection effect for the nervous centralis injury and the diffuse axonal injury, have a significant regeneration promoting effect for the injury of the myelin sheath which is the essential part of the nerve, can significantly promote the regeneration function of the peripheric movement nerve injury, and can be used for preparing the medicine for nerve injury protection and regeneration, and the defects in the aspects of protecting the nerve injury and promoting the regeneration of the injured nerve at present are overcome.

Description

technical field [0001] The invention relates to the application of Ruyizhenbao preparation in the preparation of medicines for nerve damage protection and / or regeneration promotion, and belongs to the field of medicine. Background technique [0002] Nerve injury refers to a clinical condition in which nerve conduction dysfunction, interruption of nerve axons, or nerve rupture leads to sensory, motor, and sympathetic dysfunction in the trunk and extremities, which can seriously affect the quality of life of patients. Due to the complex pathological changes after nerve injury, weak nerve regeneration ability, slow regeneration speed, adhesion of regenerated nerve to surrounding tissues, neuromuscular atrophy, degeneration of motor end plate, etc., many factors often make the treatment results unsatisfactory. [0003] At present, the clinical drugs for nerve injury mainly include nerve growth factor, fibroblast growth factor, ganglioside, mecobalamin, edaravone, hormones, etc.,...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61P25/04A61P25/28A61K35/618A61K35/612A61K35/55A61K35/413A61K35/32A61K33/10A61K33/06
CPCA61K33/06A61K33/10A61K35/32A61K35/413A61K35/55A61K35/612A61K35/618A61K36/185A61K36/23A61K36/285A61K36/286A61K36/324A61K36/47A61K36/48A61K36/482A61K36/484A61K36/54A61K36/61A61K36/71A61K36/80A61K36/835A61K36/9062A61K36/9064A61K2300/00
Inventor 张义智王海苹李丽王红月孙绪丁
Owner SHANDONG JINHE DRUG RES DEV
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