Pharmaceutical composition for treating chicken coccidiosis and preparation method thereof

Abstract

The invention discloses a pharmaceutical composition for treating chicken coccidiosis. The pharmaceutical composition is prepared from the following components by weight: 0.25 to 2.5 parts of ivermectin, 2.5 to 25 parts of antifeverile dichroa root extract, 15 to 25 parts of astragalus extract, 15 to 25 parts of dark plum extract, 10 to 15 parts of hairyvein agrimony extract and 500 parts of purified attapulgite. The invention also provides a preparation method for the pharmaceutical composition. The invention has the following advantages: the pharmaceutical composition provided by the invention has an anticoccidial index of more than 195 and is composed of both traditional Chinese medicines and western medicines; and an adjuvant material in an oral preparation is attapulgite, so slow release effect is exerted, residues are hardly left, so the pharmaceutical composition has obvious advantages. According to results of in-vitro anticoccidial sporlating test and artificial treatment effect test of chicks infected with coccidia, the traditional Chinese medicine composition provided by the invention has anticoccidial effect; so the composition facilitates further confirmation of the application scope of a compound medicine, provides related enterprises with a novel approach to develop high-quality products, broadens novel application fields of medicine resources, lays a good foundation for research and development of a novel anticoccidial medicine and is of obvious significance.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical compositions, in particular to a pharmaceutical composition for treating chicken coccidiosis and a preparation method thereof. Background technique [0002] Ivermectin is a broad-spectrum antiparasitic drug, which has a good killing effect on internal and external parasites, especially nematodes and arthropods. The insecticidal mechanism is that the drug binds to the specific high-affinity site on the target insect cells, which affects the permeability of the cell membrane to Cl-, and then causes the nerve cells of nematodes and muscle cells of arthropods to inhibit the neurotransmitter γ -The release of aminobutyric acid (GABA) is increased, and the Clˉ channel controlled by glutamic acid is opened to enhance the permeability of the neural membrane to Clˉ. The excitatory post-synaptic potential generated by the postsynaptic membrane weakens, and the post-synaptic neuron cannot enter the e...

AI Technical Summary

Problems solved by technology

Coccidia drug resistance and the resulting high morbidity and mortality have been hindering the healthy development of the chicken industry

In recent years, some progress has been made in the application of Chinese herbal medicine to the prevention and treatment of coccidiosis in chickens. It can not only prevent coccidiosis, but also solve the drug residues in meat and eggs. However, the simple application of traditional Chinese medicine is usually slow, which affects clinical application.

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