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Memantine hydrochloride sustained release-donepezil quick release compound capsule

A technology of donepezil hydrochloride and memantine hydrochloride, which is applied in the fields of pharmaceutical formulations, nervous system diseases, active ingredients of amines, etc., to achieve the effect of controllable quality and stable yield

Inactive Publication Date: 2016-02-17
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The inventors have developed an improved medicine called Memantine Hydrochloridum (MH) for treating Alzheimer's disease by slow releasing it over time with high purity. This new formulation allows patients who are unable or unwillingly take certain drugs more easily than they should be able to handle them properly without being affected from side effectiveness caused by other ingredients used during their treatment process.

Problems solved by technology

Technological Problem: The technical problem addressed in this patented patents relates to developing new treatments for neurology related diseases such as Parkinson’s disease through different combinations of these medications.

Method used

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  • Memantine hydrochloride sustained release-donepezil quick release compound capsule
  • Memantine hydrochloride sustained release-donepezil quick release compound capsule
  • Memantine hydrochloride sustained release-donepezil quick release compound capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]

[0042] Example 2

Embodiment 2

[0044]

[0045]

[0046] Embodiment 1 and embodiment 2 release contrast

[0047] Dissolution method: basket method, rotation speed 100rpm, sodium chloride-hydrochloric acid buffer solution with pH 1.2 of the dissolution medium, dissolution volume 900ml

[0048]

[0049] From the dissolution behavior of the memantine hydrochloride sustained-release-donepezil immediate-release compound capsules prepared in Example 1 and Example 2, the release behavior of donepezil meets the requirements for immediate release, and the release behavior of memantine hydrochloride meets the requirements for sustained-release drugs. The synergistic effect of the two can quickly exert the drug effect in the body, while maintaining a stable drug effect, reducing the number of times of taking the drug, and effectively improving the patient's drug compliance.

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Abstract

The invention provides a memantine hydrochloride sustained release-donepezil quick release compound capsule and a preparation method thereof. The memantine hydrochloride sustained release-donepezil quick release compound capsule is characterized in that a preparation consists of memantine hydrochloride sustained release pellets and donepezil quick release granules; each sustained release pellet sequentially comprises an empty pellet core, a medicated layer and a sustained release coating layer from inside to outside; and the donepezil quick release granules are prepared from main drugs, other fillers, a disintegrating agent, adhesive and the like. Compared with other dosage forms, the preparation has the features that two drugs are combined so that a complementary synergy effect is achieved, the number of tablets can be reduced, everyday medicine taking load is reduced, and obedience and compliance of a patient can also be improved.

Description

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Claims

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Application Information

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Owner BEIJING VENTUREPHARM BIOTECH
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