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Preparation method of manyprickle acanthopanax root extract

An acanthopanax senticosus extract and a technique for acanthopanax senticosus, which are applied in the field of preparation of acanthopanax senticosus extracts, can solve problems of unfavorable industrialized production of acanthopanax senticosus preparations, medicinal safety, influence on the quality of acanthopanax senticosus extracts, and extraction of active components. It can save production cycle, reduce solvent usage and shorten extraction cycle.

Active Publication Date: 2016-02-10
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In these prior art methods, there are slow extraction rate, long extraction cycle, low extraction rate of active ingredients, and large amount of solvent used, resulting in complicated post-treatment process and corresponding increase of impurities, which not only increases production cost, but also greatly affects It affects the quality of Acanthopanax senticosus extract in pharmaceutical preparations, which is not conducive to industrial production and the medicinal safety of Acanthopanax senticosus preparations

Method used

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  • Preparation method of manyprickle acanthopanax root extract

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Embodiment 1: Preparation of Acanthopanax Acanthopanax Extract

[0035] 1) Use 3 times the volume (15L) of 40% ethanol to countercurrently extract 5kg of Acanthopanax senticosus medicinal materials, the countercurrent extraction flow rate is 25min / can, the extraction temperature is 30°C, and the extraction time is 2 hours. Combine the extracts and concentrate to relative density 1.20 (measured at 80°C);

[0036] 2) Add 93% ethanol to make the ethanol concentration of the medicinal solution reach 75%, stir well, let it stand for 12 hours, filter the supernatant, recover the ethanol from the filtrate until it has no alcohol smell, and concentrate to a relative density of 1.11 (measured at 80°C) ;

[0037]3) Dilute with water for injection to contain about 5.0 mg / ml of total flavonoids, stir evenly, filter, adjust the pH value of the filtrate to 4.0, stir evenly, and filter the liquid through a 0.45 μm microporous membrane for clarification, then filter at 0.5 BV / h The f...

Embodiment 2

[0039] Embodiment 2: Preparation of Acanthopanax Acanthopanax Extract

[0040] 1) Use 8 volume times (32L) of 70% ethanol to countercurrently extract 4kg of Acanthopanax acanthopanax. The flow rate of countercurrent extraction is 35min / can, the extraction temperature is 80°C, and the extraction time is 0.5 hours. Combine the extracts and concentrate to relative density 1.25 (measured at 80°C);

[0041] 2) Add 98% ethanol to make the ethanol concentration of the medicinal solution reach 85%, stir well, let it stand for 24 hours, filter the supernatant, recover the ethanol from the filtrate until it has no alcohol smell, and concentrate to a relative density of 1.25 (measured at 80°C) ;

[0042] 3) Dilute with water for injection to contain about 20.0 mg / ml of total flavonoids, stir evenly, filter, adjust the pH value of the filtrate to 6.0, stir evenly, and filter the liquid through a 0.45 μm microporous membrane for clarification, then filter at 2.5 BV / h ADS-17 macroporous r...

Embodiment 3

[0044] Embodiment 3: Preparation of Acanthopanax Acanthopanax Extract

[0045] 1) Use 6 volume times (30L) of 55% ethanol to countercurrently extract 5kg of Acanthopanax acanthopanax medicinal materials, the flow rate of countercurrent extraction is 30min / can, the extraction temperature is 50°C, and the extraction time is 1 hour. Combine the extracts and concentrate to relative density 1.25 (measured at 80°C);

[0046] 2) Add 95% ethanol to make the ethanol concentration of the medicinal solution reach 80%, fully stir, let stand for 10 hours, filter the supernatant, recover the ethanol from the filtrate until it has no alcohol smell, and concentrate to a relative density of 1.20 (measured at 80°C) ;

[0047] 3) Dilute with water for injection to contain about 15 mg / ml of total flavonoids, stir evenly, filter, adjust the pH value of the filtrate to 5.0, stir evenly, and filter the medicinal solution through a 0.45 μm microporous membrane for clarification at a flow rate of 1.5...

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Abstract

The invention relates to a preparation method of traditional Chinese medicine extract, in particular to a preparation method of extract of medicine material manyprickle acanthopanax root. The manyprickle acanthopanax root extract is prepared through the procedures of conducting countercurrent extracting through ethyl alcohol with concentration of 40-70%, alcohol precipitating, resin purifying, sterilizing, concentrating and the like on medicine material manyprickle acanthopanax root. By means of the method, impurities in the manyprickle acanthopanax root extract can be remarkably reduced, the purity of effective components in the manyprickle acanthopanax root extract and the safety and stability of the manyprickle acanthopanax root extract are improved, the extract cycle can be shortened, energy conservation and high efficiency are achieved, and the method is particularly suitable for industrial production.

Description

technical field [0001] The invention relates to a method for preparing a traditional Chinese medicine extract, in particular to a method for preparing an extract of Acanthopanax senticosus. Background technique [0002] Acanthopanax senticosus (Acanthopanax senticosus) is a plant of Araliaceae. Its dried roots and stems have the medicinal effects of relaxing tendons and activating blood circulation, replenishing qi and invigorating the spleen, tonifying the kidney and calming the nerves. In the preparation of modern Chinese medicine, Acanthopanax is extracted and processed into injections, the main functions of which are to nourish the liver and kidney, benefit essence and strengthen bones, and is used to treat transient ischemic attacks caused by liver and kidney deficiency, cerebral arteriosclerosis, Cerebral thrombosis and cerebral embolism and other diseases; it is also used to treat coronary heart disease, angina pectoris combined with neurasthenia and menopausal syndro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254
Inventor 方同华许照芹刘玉成席桂才
Owner HARBIN ZHENBAO PHARMA
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