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Composition for preventing or reducing skin pigmentation and lightening skin tone and use thereof

A compound and topical composition technology, applied in skin care preparations, cosmetics, cosmetic preparations, etc., can solve problems such as easy to be oxidized, unpleasant smell and color, unstable ascorbic acid, etc., and achieve the effect of pleasant cosmetic properties

Active Publication Date: 2018-11-13
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, those whitening active ingredients have some drawbacks / disadvantages when applied in cosmetic compositions, for example: in most cosmetic compositions, ascorbic acid is unstable and easily oxidized; or when formulated in an effective dose, some plant extracts Substances in cosmetic compositions often produce unpleasant odors and colors

Method used

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  • Composition for preventing or reducing skin pigmentation and lightening skin tone and use thereof
  • Composition for preventing or reducing skin pigmentation and lightening skin tone and use thereof
  • Composition for preventing or reducing skin pigmentation and lightening skin tone and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0151] Embodiment 1: Formulation embodiment

[0152] The following examples are prepared according to the following steps

[0153] 1. Heat phase A and phase B separately to 75°C and stir the mixture until completely dissolved;

[0154] 2. Introduce B into A, and use Turboptest TM 2004 (VMI Turbotest) to stir the mixture at a speed of 2000rpm at 75°C for 10 minutes;

[0155] 3. Introduce phase C into the mixture at 50-55°C, and use Turboptest TM 2004 (VMITurbotest) at a speed of 2000rpm for 10 minutes, and then stir the resulting solution;

[0156] 4. Stir the mixture until cooled to room temperature, then neutralize with aqueous citric acid and stir until a homogeneous solution is obtained.

[0157]

Embodiment 2

[0158] Example 2: Measurement of Depigmentation Activity

[0159] The effects of the Examples on preventing or reducing skin pigmentation and / or lightening skin tone were evaluated by methods well known in the art.

[0160] Normal human melanocytes were grown and distributed in 384 plates. After 24 hours of incubation, the medium was replaced with Group 6 medium containing the raw materials to be evaluated (paeoniae root extract, ferulic acid or their combination) and the positive control lucinol. Cells were incubated for 72 hours before a final measurement of optical density, which measures the amount of melanin produced by melanocytes.

[0161] Group

Composition (g / l)

depigmentation activity

1

1g / L lucinol

100

2

0.25g / L Peony Root Extract (Paeoniae Alba)

0

3

0.125g / L of ferulic acid

62

4

0.125g / L ferulic acid and 0.125g / L peony root extract (white peony root)

100

5

0.25g / L ferulic acid

119

...

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Abstract

The present invention relates to a topical composition comprising the combination of the extract of a plant in the family Paeoniaceae and at least one compound of formula (I), and use thereof for preventing or decreasing skin pigmentation and / or lightening skin tone, wherein R1, R2 and R3 are as defined in the specification.

Description

technical field [0001] The invention relates to the field of skin care cosmetics. More specifically, the present invention relates to a topical composition for preventing or reducing skin pigmentation and / or lightening skin tone and its use. Background of the invention [0002] Skin pigmentation control remains one of the key factors in achieving ideal skin in Asians, and this translates into a huge cosmetic market for skin care products in Asia. For example, according to some studies, in China, whitening products accounted for more than 35% of the total skin care product market, and continued to grow at a relatively high speed of 15% in 2011. The situation is similar in other Asian countries such as Japan, South Korea, India and Indonesia. [0003] In the prior art, active ingredients having melanin production inhibiting activity are used in whitening cosmetic compositions in order to prevent or lighten dark complexion or spots on the skin. For example, ascorbic acid and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/33A61K8/34A61K8/37A61K8/9789A61K8/96A61K8/18A61K8/30A61Q19/00A61Q19/02
CPCA61K8/365A61K8/4973A61K8/9789A61Q19/02
Inventor 周亮S.约伊林L.鲍克斯林欣荣
Owner LOREAL SA
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