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Solid dispersion capsule for treatment of peptic ulcer

A solid dispersion capsule and solid dispersion technology, applied in the digestive system, capsule delivery, medical preparations of non-active ingredients, etc., can solve the problems of high cost, high medicinal taste, large amount of medicinal materials, etc., and achieve improved anti-ulcer activity and pain relief Good effect, the effect of improving bioavailability

Inactive Publication Date: 2016-01-13
门源县雪草木生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned prescriptions have more medicinal flavors, a larger amount of medicinal materials, and higher costs

Method used

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  • Solid dispersion capsule for treatment of peptic ulcer
  • Solid dispersion capsule for treatment of peptic ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0027] Zushima 3g, Anisopolamine 0.5g, Dried Ginger 9g, Seabuckthorn 10g; after drying, crush to 300 mesh, mix evenly to get raw material medicine powder.

[0028] Take raw drug powder: polyethylene glycol-6000=1:1w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

[0029] Capsule the solid dispersion to obtain solid dispersion capsules.

Embodiment 2

[0030] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0031] Zushima 1g, Anisopolamine 0.6g, Dried Ginger 6g, Seabuckthorn 10g; after drying, crush to 400 mesh, mix evenly to get the raw material medicine powder.

[0032] Take raw drug powder: polyethylene glycol-6000=1:3w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

[0033] Capsule the solid dispersion to obtain solid dispersion capsules.

Embodiment 3

[0034] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0035] Zushima 1g, anisopolamine 0.3g, dried ginger 10g, seabuckthorn 6g; after drying, crush into 500 meshes, and mix well to obtain the raw material medicine powder.

[0036] Take raw drug powder: polyethylene glycol-6000=3:1w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, pulverize to obtain Solid dispersion.

[0037] Capsule the solid dispersion to obtain solid dispersion capsules.

[0038] The beneficial effects of the present invention are further demonstrated through specific test examples below.

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Abstract

The invention provides a solid dispersion capsule for treatment of a peptic ulcer. The solid dispersion capsule is prepared by being filled with a solid dispersion. The solid dispersion is prepared by bulk drug powder which meets the condition that polyethylene glycol-6000=1-3:1-3 w / w. The bulk drug powder is obtained by smashing bulk drugs comprising, by weight, 1-3 parts of girald daphne bark, 0.3-0.6 part of scopolia tangutica, 6-10 parts of dried ginger and 6-10 parts of sea-buckthorn into 300-500 meshes. According to the solid dispersion capsule for treatment of the peptic ulcer, the bulk drug powder is prepared into the solid dispersion capsule, so that the bioavailability of the drug is improved, and anti-ulcer activity is improved obviously; however, the solid dispersion has the main defect that ageing caused by oxidation can happen easily in the storing process, and thus the dissolving-out speed is decreased; accordingly, the solid dispersion is prepared into the capsule, direct contact of the air and the solid dispersion is isolated through a capsule shell, and therefore the ageing speed is decreased.

Description

technical field [0001] The invention relates to a solid dispersion capsule for treating peptic ulcer. Background technique [0002] Gastric and duodenal ulcers refer to localized round or oval full-thickness defects of gastric and duodenal mucosa, the muscularis mucosae is penetrated, and fibrous scars inevitably remain after healing, with a layer of epithelium on the surface Overlying, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic erosive gastritis, also known as verrucous gastritis or pimple-like gastritis, generally only sees dyspepsia symptoms such as fullness after meals, pantothenic acid, belching, and irregular abdominal pain. Multiple verruc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K47/34A61K9/48A61P1/04
Inventor 徐继锋卞海军许婧
Owner 门源县雪草木生物药业有限公司
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