Pancreatic leakage detection agent based on divalent cobalt ions and application of pancreatic leakage detection agent

Abstract

The invention relates to the technical field of medical detection, in particular to a pancreatic leakage detection agent based on divalent cobalt ions and application of the pancreatic leakage detection agent. The pancreatic leakage detection agent is a solution containing divalent cobalt compound or is a water absorption material loaded with divalent cobalt compound, and is prepared by dissolving divalent cobalt compounds in solvent to prepare a solution or dropwise adding the divalent cobalt compounds to the water absorption material after the divalent cobalt compounds are dissolved in solvent. The divalent cobalt compounds are one of all cobalt-containing compounds which can generate divalent cobalt ions in solvent through ionization. By means of the pancreatic leakage detection agent, tissue liquid with pancreatic juice and tissue liquid without pancreatic juice can be distinguished through obvious color changes under the condition of low-dosage pancreatic juice, the high detection flexibility and the large detection range are achieved, and the pancreatic leakage detection agent is safe and reliable.

Description

technical field [0001] The invention relates to the technical field of medical detection, in particular to a divalent cobalt ion-based pancreatic leakage detection agent and its application. Background technique [0002] Pancreatic fistula is the most common and serious complication after pancreatic surgery, and it is one of the main causes of severe abdominal infection and hemorrhage after pancreatic surgery. The main cause of pancreatic fistula is that after surgical suturing, there are small cracks in some places due to surgical sutures, and pancreatic juice leaks (pancreatic leakage). However, pancreatic juice is a colorless and odorless liquid, so doctors cannot immediately and accurately judge whether there is pancreatic juice leakage after surgical suture. How to visualize pancreatic juice leakage becomes the key to preventing pancreatic fistula. [0003] The concentration of bicarbonate in pancreatic juice is high, the highest concentration can reach 140mmol / L, doze...

AI Technical Summary

Problems solved by technology

However, the color range of litmus paper is 5.0 to 8.0, and the color change is not obvious in the physiological pH and pancreatic juice pH range. The pH of pancreatic juice is often lower than 8.0, and the litmus test paper is even more useless at this time. At the same time, litmus has a high requirement for the leakage of pancreatic juice. Sometimes, secretin is injected intravenously to stimulate the secretion of pancreatic juice. Leakage tends to be small (20 μl), which also greatly limits the use of litmus paper

Moreover, the safety of the litmus test paper is unknown, and may bring other side effects to patients, and it remains to be discussed whether it will actually be used clinically

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