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Application of salsalate compound in preparing drugs for restraining metastases and diffusion of colon cancer cells

A technology of disalicylate and colon cancer cells, applied in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc., can solve problems such as the pharmacological effects of disalicylate compounds that have not yet been discovered, reduce the research and development cycle and reduce death volume effect

Inactive Publication Date: 2015-12-30
NANJING WENZHI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Other pharmacological effects of salicylate compounds have not been found in the existing published literature

Method used

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  • Application of salsalate compound in preparing drugs for restraining metastases and diffusion of colon cancer cells
  • Application of salsalate compound in preparing drugs for restraining metastases and diffusion of colon cancer cells
  • Application of salsalate compound in preparing drugs for restraining metastases and diffusion of colon cancer cells

Examples

Experimental program
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Embodiment 1

[0020] Example 1: Application of a salicylate compound as a drug for inhibiting the metastasis and spread of colon cancer cells. The specific experimental plan is as follows:

[0021] Colon cancer cells (HT29) were used in the experimental phase of the present invention, and nocodazole (experimental concentration: 10uM) was used as the positive control. The blank control group received no treatment.

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Abstract

The invention discloses an application of a salsalate compound in preparing drugs for restraining metastases and diffusion of colon cancer cells. The drugs prepared through the salsalate compound are utilized for restraining the metastasis capacity of the tumor cells, and the salsalate compound is a low-toxin drug, and achieves a large blocking effect in the metastasis process of tumors. Meanwhile, other related tumor drugs are adopted for treatment, and the number of dead normal cells can be greatly reduced. Most of existing tumor drugs are cytotoxic drugs, and a large number of normal cells die while the tumor cells are killed.

Description

technical field [0001] The invention relates to a new application of a disalicylate compound in the field of pharmacy, in particular to the application of a disalicylate compound as a medicine for inhibiting the metastasis and spread of colon cancer cells. Background technique [0002] Salicylic acid drugs are common non-steroidal anti-inflammatory drugs, which are widely used as antipyretic, analgesic, anti-inflammatory and anti-rheumatic drugs, and their effects of lowering blood sugar and preventing and treating thrombotic diseases have also attracted attention. [0003] Disalicylate is similar to aspirin in that it has antipyretic, analgesic and anti-inflammatory effects. Oral administration does not decompose in the stomach, but decomposes into two molecules of salicylic acid in alkaline intestinal juice to work, reaching a higher blood concentration, and the therapeutic blood concentration can be maintained for 16 hours. After oral administration, it is insoluble in g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/618A61P35/04
Inventor 董梅
Owner NANJING WENZHI BIOTECH
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