Patch Clamp Microelectrode and Holder for Coaxial Photoactivation

A patch clamp and microelectrode technology, which is applied to instruments, scientific instruments, material analysis by electromagnetic means, etc., can solve the problems of complex process and high price, and achieve the effect of low cost and simple structure.

Inactive Publication Date: 2017-11-17
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For these two technologies, the former does not form a complete experimental equipment, but is only a temporary experimental method; the latter requires special electron beam deposition equipment to process metal conductive layers, which is complicated and expensive

Method used

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  • Patch Clamp Microelectrode and Holder for Coaxial Photoactivation
  • Patch Clamp Microelectrode and Holder for Coaxial Photoactivation
  • Patch Clamp Microelectrode and Holder for Coaxial Photoactivation

Examples

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Embodiment Construction

[0023] Below in conjunction with accompanying drawing and embodiment the present invention will be further described: as figure 1 As shown, it includes a glass tube 1, an electrode 2 and a holder 3. The holder 3 includes a mirror 3.1, an optical fiber interface 3.2 and a catheter interface 3.3.

[0024] One input end of the glass tube 1 is connected with the output end of the holder 3; the input end of the optical fiber interface 3.2 is connected with the optical fiber of the external light source; the input end of the catheter interface 3.3 is connected with the external catheter; the output of the glass tube 1 The terminal of electrode 2 is connected with the sample to be measured; the input terminal of electrode 2 is connected with the inner liquid of the electrode filled with the tip of glass tube 1; the output terminal of electrode 2 is connected with the external patch clamp amplifier. The tip of the glass tube 1 is filled with a small amount of conductive electrode li...

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Abstract

A patch clamp microelectrode and a holder for coaxial photoactivation, which includes a glass tube, an electrode and a holder. The holder includes a mirror, an optical fiber interface and a catheter interface. The patch-clamp microelectrodes and holders that can be used for coaxial photoactivation use the method of partially filling the glass tube with high refractive index liquid to realize the liquid-core light guide, and transmit the external laser light to the cells that are in contact with the glass tube microelectrodes to complete the light. activation. The patch clamp microelectrode and holder that can be used for coaxial photoactivation can complete the photoactivation of cells and the recording of electrophysiological signals in situ. The invention has the advantages of simple structure, low cost and convenience, and is of great significance for neuroscience research.

Description

technical field [0001] The invention relates to a patch-clamp microelectrode and a holder that can be used for coaxial photoactivation, especially the method of partially filling the glass tube microelectrode with a high refractive index liquid to realize the liquid core light guide, and transmit the external laser light to the Cells are contacted with glass tube microelectrodes to achieve photoactivation. The patch-clamp microelectrode and holder that can be used for coaxial photoactivation can complete the photoactivation of cells and the recording of electrophysiological signals in situ. Background technique [0002] As an electrophysiological technique widely used in life science research, patch clamp technology provides an advanced research method for solving the transmembrane signal transduction of biological information. The working principle of the patch clamp technique is to use a glass microelectrode to seal the cell membrane with only 1-3 ion channels and an area...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/416
Inventor 徐英舜王索刚刘楠楠刘爱丽谌辉
Owner TIANJIN MEDICAL UNIV
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