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Purification method of creatine phosphate sodium

A technology of creatine phosphate sodium and a purification method, which is applied in chemical instruments and methods, compounds of group 5/15 elements of the periodic table, organic chemistry, etc., and can solve problems such as low production efficiency and low solubility of creatine phosphate calcium, Achieve high production efficiency and good safety

Active Publication Date: 2015-12-16
XINAN PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some resin separation methods use calcium chloride for elution. Although no sulfate and barium are introduced, the production efficiency of this method is also very low due to the extremely low solubility of calcium creatine phosphate in water.

Method used

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  • Purification method of creatine phosphate sodium
  • Purification method of creatine phosphate sodium
  • Purification method of creatine phosphate sodium

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Embodiment Construction

[0028] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings. For the experimental methods that do not specify specific conditions in the examples, usually follow the conventional conditions or the conditions suggested by the manufacturer.

[0029] The purified creatine phosphate sodium sample in the present invention is that the molar ratio of creatine: ATP is in the range of 2:1 to 10:1, the reaction time is about 6h, the temperature is in the range of 5 to 40°C, and the pH is in the range of 9 to 40°C. 11. The concentration of magnesium ions should be within the range of 0.5 to 1.5 times the concentration of ATP. The product of the reaction under the catalysis of immobilized rabbit creatine kinase is hereinafter referred to as sodium creatine phosphate mother liquor. The mother liquor contains a large amount of creatine, creatine sodium phosphate, ADP, ATP, magnesium ions, and a small amount of AMP a...

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Abstract

The invention discloses a purification method of creatine phosphate sodium, which comprises the following steps: pretreating a creatine phosphate sodium mother solution with 40-70 vol% ethanol, loading the pretreated creatine phosphate sodium mother solution, eluting creatine by using a 0.02-0.15M electrolyte solution as an eluent, eluting the creatine phosphate sodium by using a 0.2-0.8M electrolyte solution as an eluent, collecting the eluate, crystallizing, and drying to obtain the creatine phosphate sodium. The method is simple, does not need to introduce sulfates or barium, and has high safety. The recovery rate of the prepared creatine phosphate sodium is high and up to 40%, and the purity reaches 99.80%, thereby satisfying the medicinal requirements.

Description

technical field [0001] The invention belongs to the field of chemistry, and in particular relates to a purification method of creatine phosphate sodium. Background technique [0002] Phosphocreatine is an active substance in the human body. The substance is currently used clinically in the form of creatine phosphate sodium tetrahydrate, mainly for the treatment of cardiovascular diseases and metabolic diseases. The drug has a huge market, broad prospects, and a wide range of drug users. In literature reports, the existing purification process of sodium creatine phosphate is precipitation method or resin separation method. The precipitation method will introduce sulfate and barium ions; the resin separation method used by Jilin Yinglian Pharmaceutical Company also introduces sulfate and barium ions; the above two ions are very toxic, so the residue in the product is required to be very low , and this requirement increases the difficulty of purification and crystallization,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/22
Inventor 陈真文廖凤霞李玉林程永刚肖中元郭伟毛先兵
Owner XINAN PHARMA
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