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Collagen dressing plaster and preparing method and application thereof

A collagen, medical technology, applied in the field of medicine and health, can solve irritation and other problems

Active Publication Date: 2015-12-09
陕西艾尔肤组织工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Disclosed medical collagen dressings in the prior art adopt small molecule collagen (as fish collagen) to make medical collagen dressings, and in the gained medical collagen dressings, due to adding traditional preservatives such as potassium sorbate, benzoic acid, methylparaben, etc. , such as potassium sorbate, benzoic acid, methylparaben, etc. have certain irritation to the skin, and are not suitable for the treatment and care of facial allergic skin diseases, facial burns and other wounds, facial laser, photon therapy and other surgical procedures. Post repair and care

Method used

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  • Collagen dressing plaster and preparing method and application thereof
  • Collagen dressing plaster and preparing method and application thereof
  • Collagen dressing plaster and preparing method and application thereof

Examples

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preparation example Construction

[0054] In a third aspect, embodiments of the present invention provide a method for preparing a collagen dressing, see figure 1 ,include:

[0055] S1. Fully dissolving the collagen solution containing macromolecular collagen and small molecular collagen in a dilute acid solution with a mass concentration of 0.05% to 0.1% to obtain an initial collagen solution; wherein, the molecular weight of the macromolecular collagen Greater than or equal to 300KD, the molecular weight of the small molecule collagen is less than 300KD;

[0056] S2. Adding a medical preservative solution to the primary collagen solution to obtain a collagen solution;

[0057] S3. Pour the collagen solution into a sterile aluminum foil bag, seal and package to obtain the collagen dressing, and place a matrix for attaching the collagen solution in the sterile aluminum foil bag.

[0058] The embodiment of the present invention provides a method for preparing a collagen dressing. Collagen is obtained by fully ...

specific Embodiment approach

[0096] The following examples are just examples to specifically illustrate the present invention, and those skilled in the art can understand that the scope of the present invention is not limited by these examples.

[0097] Illustrative only, in the described embodiment, macromolecular collagen and small molecular collagen of the embodiment of the present invention can adopt acid method to extract type I collagen protein from newborn cow hide, also can adopt acid enzyme combination method to extract from Type I collagen extracted from cowhide of newborn cows.

Embodiment 1

[0099] Fully dissolving the collagen solution containing macromolecular collagen and small molecular collagen at a concentration of 2 mg / mL in a citric acid solution with a mass concentration of 0.1% at 6°C for 8 hours to obtain an initial collagen solution; wherein, the large The molecular weight of the molecular collagen is greater than or equal to 300KD, and the molecular weight of the small molecular collagen is less than 300KD;

[0100] Add phenoxyethanol with a concentration of 0.5% to the initial collagen solution to obtain a collagen solution with a mass concentration of 0.5 mg / mL, and adjust the pH of the collagen solution to 4.0 with 1 moL / L NaOH solution;

[0101] 20mL of the collagen solution is poured into a sterile aluminum foil bag, sealed and packaged to obtain the collagen dressing, and a non-woven fabric for attaching the collagen solution is placed in the sterile aluminum foil bag.

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Abstract

The embodiment of the invention provides a collagen dressing plaster and a preparing method and application thereof, and relates to the field of medicine and health. The collagen dressing plaster is used for treating and caring acne, facial allergic dermatitis, facial burns and scalds and other wound surfaces. The preparing method includes the steps that a collagen solution containing macromolecular collagen and micromolecular collagen is fully dissolved in a diluted acid solution with the mass concentration of 0.05-0.1% to obtain a collagen solution; a small amount of medical preservative solution is added into the collagen solution; a sterile aluminum foil bag is filled with the collagen solution, sealed and packaged to obtain the collagen dressing plaster, and a matrix used for the collagen solution to adhere to is put in the sterile aluminum foil bag. The collagen dressing plaster is used for postoperative repair and caring after facial laser and photon treatment to have the effects of promoting wound healing and rebuilding and recovering skin barrier functions.

Description

technical field [0001] The invention relates to the field of medicine and hygiene, in particular to a collagen dressing and a preparation method and application thereof. Background technique [0002] Collagen is a biological polymer substance synthesized by fibroblasts. It is the most abundant and widely distributed protein in the human body. It is mainly distributed in skin, ligaments, tendons, cartilage and other parts. It plays a role in maintaining the morphological structure of the skin and various tissues and organs, and is also an important raw material for repairing various damaged tissues. Due to the advantages of high hydrophilicity, low toxicity, weak antigenicity, good biocompatibility, and complete biodegradability of collagen, it is widely used in burns, trauma, corneal diseases, cosmetics, orthopedics, hard tissue repair, and wounds. It is widely used in medical and health fields such as hemostasis. For example, active collagen solution and pure cotton non-w...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/44A61K38/39A61K9/70A61P17/00A61P17/10A61P37/08A61P17/02
Inventor 何宁杨苹张爱兵
Owner 陕西艾尔肤组织工程有限公司
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