Establishment and application of rhesus monkey pulmonary fibrosis model

Abstract

The invention discloses a method for preparing an animal pulmonary fibrosis model. According to the method, bleomycin is applied to a primate, the application dose of the bleomycin is 7 mg / Kg for each time, and application is performed once for each week and totally performed twice. The invention further provides a rhesus monkey pulmonary fibrosis model prepared with the method and an application of the rhesus monkey pulmonary fibrosis model. The rhesus monkey pulmonary fibrosis model is established successfully, an operation process is simple and easy to repeat, and the model can be used for new biotechnological drug evaluation which cannot be finished by a rodent model and has bright clinical application prospects.

Description

technical field [0001] The invention relates to a preparation method and application of a rhesus monkey pulmonary fibrosis model. Background technique [0002] Pulmonary fibrosis is a major disease that affects human health. The cause of the disease is unknown. So far, there is no effective prevention and treatment. Although the commonly used mechanical ventilation and hormone therapy can alleviate the patient's dyspnea and hypoxemia to a certain extent, long-term use of hormone therapy may induce other diseases, and the cost of mechanical ventilation is high, and the operation is not easy. None of the above treatment methods can fundamentally cure pulmonary fibrosis, nor improve the survival rate. How to prevent the spread of pulmonary fibrosis, effectively inhibit the growth of fibroblasts in the lung, and fundamentally block fibrosis is the key point of current research [0003] The most commonly used model for pulmonary fibrosis research today is the rodent. Because r...

AI Technical Summary

Problems solved by technology

Since the current pulmonary fibrosis treatment drugs and methods cannot effectively control the spread of fibrosis, there is an urgent need to establish a non-human primate pulmonary fibrosis model to provide evaluation for new drugs and targeted therapies

[0004] Currently, there is no report on the establishment of a rhesus monkey model of pulmonary fibrosis

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