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Extraction method and application of garlic-containing plant combination

An extraction method and composition technology, which is applied in the direction of drug combinations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of large dosage, backwardness, and many impurities for patients, and achieve the effect of reducing dosage

Inactive Publication Date: 2015-12-02
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of garlic-containing plant compositions. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients, which is inconvenient to take, and seriously Affected the clinical application of this product

Method used

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  • Extraction method and application of garlic-containing plant combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 70 parts of garlic, 60 parts of ancient sheep vine, 40 parts of mountain willow chrysanthemum, and 50 parts of water weng flower, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400-600W, and the extraction time is 2 4-8 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry, The microwave extract was obtained, and conventional excipients were added to prepare tablets, each tablet 0.4g.

Embodiment 2

[0016] Take 70 parts of garlic, 60 parts of ancient sheep vine, 40 parts of mountain willow chrysanthemum, and 50 parts of water weng flower, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400-600W, and the extraction time is 2 4-8 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry, The microwave extract is obtained, and conventional auxiliary materials are added to prepare capsules.

Embodiment 3

[0018] Take 70 parts of garlic, 60 parts of ancient sheep vine, 40 parts of mountain willow chrysanthemum, and 50 parts of water weng flower, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400-600W, and the extraction time is 2 4-8 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry, The microwave extract is obtained, and conventional auxiliary materials are added to prepare granules.

[0019] Ancient sheep vine is a plant of the genus Ma Lian'an in the family Rutaceae, Ma Lian'an Streptoculongriffithii Hook.f. It is used as medicine with its roots. Harvested throughout the year, used fresh or sun-dried. Heat-clearing and toxic substances removing, dissipating silt and relieving pain. For cold and fever, enteriti...

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Abstract

The invention provides an extraction method of a garlic-containing plant combination. The garlic-containing plant combination is prepared from 70 parts of garlic, 60 parts of griffith streptocaulon root or leaf, 40 parts of hawkweed and 50 parts of water banyan as raw medicines by adopting a microwave extraction method. The content is greatly increased, and the dose is reduced. The invention also provides application of the garlic-containing plant combination in preparation of medicines for inhibiting cell proliferation of mouse mastocytoma P815.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an extraction method and application of a plant composition containing garlic. Background technique [0002] The plant composition containing garlic is made of 70 parts of garlic, 60 parts of ancient sheep vine, 40 parts of chrysanthemum, and 50 parts of water wenghua as raw materials. The current extraction method is to add water and decoct twice, each time 2-3 hours, combined decoction, filtered, concentrated into a thick paste, granulated, dried, sugar-coated, that is. [0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of garlic-containing plant compositions. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients, which is inconvenient to take, and seriously Affected the clinical application of this prod...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61P35/00
Inventor 赵明亮
Owner NANJING ZHENGLIANG MEDICAL TECH
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