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Application of 23-trans-para-coumaroyl tormentic acid compound

A technology of coumaryl compounds, applied in the field of botanical fungicides, can solve the problem of no biological activity research, etc., and achieve the effects of good inhibitory activity, low pesticide residues, and good environmental compatibility

Active Publication Date: 2015-12-02
SHANDONG XINGHE CROP SCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on further research on the biological activity of the compound

Method used

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  • Application of 23-trans-para-coumaroyl tormentic acid compound
  • Application of 23-trans-para-coumaroyl tormentic acid compound
  • Application of 23-trans-para-coumaroyl tormentic acid compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] 23-trans-p-coumaroyltormentic acid represented by formula (1) is a known compound of ursane type.

[0013] The preparation process of 23-trans-p-coumaroyl polinic acid shown in formula (1) can be referred to in literature deTommasiN, deSimoneF, PizzaC, etal. 8): The description in 1067-1073 is carried out.

Embodiment 2

[0014] Embodiment 2: antibacterial activity test

[0015] The microdilution method was used to determine the antibacterial activity of the compound shown in formula (1) against Botrytis cinerea ("From Natural Products to New Pesticide Development-Principle and Method", Wu Wenjun, 2006, Chemical Industry Press).

[0016] 1) Preparation of bacterial suspension

[0017] Inoculate the fungus to be tested on the surface of PDA medium and culture at 28°C for 72 hours, draw 2 mL of sterile 0.85% NaCl solution (containing 0.25% Tween-20) to wash the culture, and gently scrape off the colony with a glass scraper. Draw an appropriate amount of bacterial suspension into a sterile test tube and adjust to 0.5 McFarland turbidity (equivalent to 1.5×10 8 CFU / mL), spare;

[0018] 2) Sample preparation

[0019] Take 1 mg of the sample to be tested (compound of formula (1)) and positive control (amphotericin B) respectively, dissolve in 100 μ D DMSO, mix well, draw 50 μ L of the sample solut...

Embodiment 3

[0026] Embodiment 3: wettable powder

[0027] Formula (weight ratio): 20% of 23-trans-p-coumaroyl-poisonic acid powder, 20% of white carbon black, 5% of sodium lauryl sulfate, 1.0% of CMC and 3.0% of pull-off powder, Attapulgite residue.

[0028] Preparation method: Mix the above-mentioned raw materials evenly, control the processing temperature at 0-50°C, and pulverize them to more than 150 mesh in a jet mill or other high-mesh mills, control the water content at 6-8% (mass percentage), pH Control it at 7-7.5.

[0029] How to use: Spray with 600 times liquid, and spray evenly on the leaves of the plant.

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PUM

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Abstract

The invention discloses application of a 23-trans-para-coumaroyl tormentic acid compound. The structure of the compound is shown as a formula (I). The application has the advantages that the activity of borrytis cinerea can be effectively inhibited by the 23-trans-para-coumaroyl tormentic acid compound, the minimum inhibition concentration is 4 micrograms / mL, and the 23-trans-para-coumaroyl tormentic acid compound can be used as a novel pesticide component or a lead compound with a sterilization effect; the compound shown as the formula (1) is a botanical natural product and is low in toxicity and pesticide residue and excellent in environment compatibility, and the like.

Description

technical field [0001] The invention relates to a botanical fungicide, in particular to the application of a derivative of polingenic acid. Background technique [0002] As one of the main cultivated vegetables in my country, cucumber has high economic value, but the economic losses caused by plant diseases every year are difficult to estimate. Cucumber botrytis is one of the most difficult plant diseases to control in cucumber production. Although chemical pesticides can play a good control role, frequent use is prone to produce resistance, and there are toxic side effects and residual problems on humans and animals. Plant-derived fungicides have the advantages of good biological activity, safety to non-target organisms, and good environmental compatibility, and have become a hot spot in the research and development of new pesticides. [0003] DeTommasi et al. isolated four new ursane-type triterpene acids from the chloroform extract of loquat leaves from Italy: 23-trans-p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N45/00A01P3/00
Inventor 牛赡光杜丰玉张淑静李清和
Owner SHANDONG XINGHE CROP SCI TECH CO LTD
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