Down's syndrome risk assessment method for prenatal screening in pregnant metaphase

Abstract

The present invention discloses a Down's syndrome risk assessment method for prenatal screening in pregnant metaphase, which includes the following steps: 1) collecting serological index testing results of pregnant women who meet the requirement of age, gestation age and weight; 2) determining gestation ages; 3) determining a median of a serological index of normal pregnant women of each of pregnancy days to obtain a regression formula of the median of the serological index of the normal pregnant women of each of pregnancy days relative to pregnancy days; 4) determining a multiple of the median of the tested pregnant women; 5) adjusting the multiple of the median of the tested pregnant women by the regression formula; 6) establishing a coefficient of a risk assessment formula of Down's syndrome by Logistic regression; 7) establishing the risk assessment formula of a triple test scheme and a double test scheme of Down's syndrome. The method based on pregnancy days and applied to prenatal screening aims at Chinese pregnant women, and has high positive rate and low false positive.

Description

technical field [0001] The invention relates to a method for calculating the risk of Down's syndrome in prenatal screening in the second trimester, belonging to the field of medical clinical diagnosis. Background technique [0002] There are 1 million birth defects in China every year, and only 30% of them can be cured or corrected. Since the incidence of birth defects is very stable and there is no effective treatment, the key to reducing birth defects lies in prevention and prenatal screening. and diagnosis. [0003] At present, the methods and software used in China's prenatal screening are all software developed abroad. Most of the models used in the software are risk estimation methods established by foreign experts in the 1980s, using a multivariate normal model. The data distribution of each variable is required to be a normal distribution, and there are many restrictions when using it. The principle of these methods and software is to collect data from foreign norma...

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Problems solved by technology

[0003] At present, the methods and software used in China's prenatal screening are all software developed abroad. Most of the models used in the software are risk estimation methods established by foreign experts in the 1980s, using a multivariate normal model. The data distribution of each variable is required to be a normal distribution, and there are many restrictions when using it. The principle of these methods and software is to collect data from foreign normal and diseased populations (such as North Caucasians), and establish a judgment model. Domestic normal pregnant women The values ​​of serological indicators in the population are significantly different from those of normal pregnant women abroad, resulting in deviations in test results

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