Method for correcting multiple of median of serum marker in second-trimester prenatal screening

Abstract

The invention discloses a method for correcting multiple of median of a serum marker in second-trimester prenatal screening. The method is characterized by comprising the following steps of: (1) acquiring related data, such as a serum marker detection result, weight and the like of a pregnant woman with age, gestational age and weight meeting the requirement; (2) determining the gestational age (day) based on gestational day; (3) determining the median of the serum marker of a normal pregnant woman group on each gestational day to obtain a regression formula of the median of the serum marker of the normal pregnant woman group relative to the day on each gestational day; (4) determining the multiple of the median of a detected pregnant woman; and (5) correcting the multiple of the median of the detected pregnant woman by using a weight regression formula. The method is applied to the gestational day-based prenatal screening established special for a Chinese pregnant woman group, and has the advantages of high detection ratio and low false positive.

Description

technical field [0001] The invention relates to a method for correcting the median multiple of serological indexes in prenatal screening in the second trimester, and belongs to the field of medical clinical diagnosis. Background technique [0002] There are 1 million birth defects in China every year, and only 30% of them can be cured or corrected. Since the incidence of birth defects is very stable and there is no effective treatment, the key to reducing birth defects lies in prevention and prenatal screening. and diagnosis. Prenatal screening refers to the detection of high-risk pregnant women with certain congenital defects from among pregnant women through economical, simple and less invasive detection methods, and prenatal diagnosis is carried out to minimize the birth of abnormal fetuses. [0003] At present, the methods and software used in China's prenatal screening are all software developed abroad. The principle of these methods and software is to collect data fro...

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Problems solved by technology

[0003] At present, the methods and software used in China's prenatal screening are all software developed abroad. The principle of these methods and software is to collect data from foreign normal and diseased populations (such as North Caucasians) and establish a judgment model, so that Prenatal screening technology has made some progress and success in terms of sensitivity, specificity, false positive rate control, etc., but due to factors such as race, pregnant woman's weight, and region, the probability distribution of MOM value and weight probability distribution between domestic and foreign countries There are differences between them. The values ​​of serological indicators of normal pregnant women in China are significantly different from those of normal pregnant women abroad, resulting in deviations in test results. If the foreign prenatal screening method is used directly, the median value of serological indicators obtained will be Applying multiple values ​​to prenatal screening of pregnant women will lead to an increase in false positives, a large number of positive pregnant women will be missed, and the screening efficiency will be reduced. Therefore, it is necessary to correct the median multiple of serological indicators in the second trimester prenatal screening. Key technologies for the efficiency of prenatal screening

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