Diagnosis marker suitable for early-stage esophageal squamous cell cancer diagnosis and screening method of diagnosis marker

Abstract

The invention discloses a diagnosis marker suitable for an early-stage esophageal squamous cell cancer diagnosis and a screening method of the diagnosis marker. Twenty five kinds of serum metabolic markers and ten relevant metabolic pathways are discovered; through the combination of the twenty five kinds of serum metabolic markers, the diagnosis marker used for an esophagus cancer diagnosis can be obtained. The screening method of the diagnosis marker has high operability; the diagnosis marker can be used for building a diagnosis model; the diagnosis model has the advantages of good effect, high sensitivity and good specificity, is suitable for a late-stage esophagus cancer diagnosis and is also suitable for the early-stage esophagus cancer diagnosis. The diagnosis model built by adopting the diagnosis marker provided by the invention has the advantages that the diagnosis can be realized only through blood sampling; the noninvasive effect is achieved; the cost is low; the modern internal invasive diagnosis mode can be well replaced; the pain of a patient is greatly reduced; in addition, the diagnosis speed is high; convenience is realized; the required time is short; the work efficiency is improved; the early discovery and early treatment of an esophagus cancer can be favorably realized; good clinic use and popularization value is realized.

Description

technical field [0001] The present invention relates to the diagnosis of esophageal squamous cell carcinoma, in particular to a diagnostic marker for esophageal squamous cell carcinoma, a screening method for the diagnostic marker, a diagnostic model based on the diagnostic marker, and a method for constructing the diagnostic model. The diagnostic marker and diagnostic model have good diagnostic effects on esophageal carcinoma in situ, early and advanced esophageal cancer, are particularly suitable for early diagnosis of esophageal cancer, and belong to the technical field of diagnosis of esophageal squamous cell carcinoma. Background technique [0002] Esophageal cancer is a malignant lesion formed by abnormal proliferation of esophageal squamous epithelium or glandular epithelium. According to the latest data from the World Health Organization, about 400,000 people die from esophageal cancer every year in the world. my country is the country with the highest incidence and ...

AI Technical Summary

Problems solved by technology

[0007] Aiming at the shortcomings of esophageal squamous cell carcinoma (referred to as esophageal cancer) in the prior art, which are complex, expensive, and traumatic, and the current markers are only highly sensitive to advanced esophageal cancer, and cannot achieve early diagnosis of esophageal cancer, this paper The invention provides a diagnostic marker suitable for the early diagnosis of esophageal squamous cell carcinoma. The diagnostic marker has good sensitivity and specificity for esophageal carcinoma in situ, early esophageal cancer, and advanced esophageal cancer. It can not only be used for The diagnosis of advanced esophageal cancer can also be better used for the early diagnosis of esophageal squamous cell carcinoma, which is of great significance for improving the prognosis and reducing mortality of esophageal squamous cell carcinoma

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