Method for continuously and comprehensively extracting liquorice ingredient with high pressure

Abstract

The invention provides a method for continuously and comprehensively extracting the liquorice ingredient with high pressure. The method comprises the steps that high-pressure digestion is continuously carried out, wherein water is utilized for mixing smashed liquorice into pulp, a high-pressure pump is utilized for pushing the pulp into a high-pressure digestion container, and the pulp is continuously fed and discharged within the pressure bearing time to achieve liquid state digestion; two-stage flocculation and purification are carried out, wherein water is used for diluting the pulp high-pressure digested materials, then filtering is carried out to obtain filtered clear liquid, and tannin, heavy metal and protein in the filtered clear liquid are removed; complexing separation is carried out, wherein a complexing agent is utilized for dividing deeply-purified liquid into solid and liquid phases; follow-up purification is carried out, wherein the PH value of the liquid phase is adjusted by dilute acid for precipitation, ethyl alcohol for precipitation is used for reflux extraction and filtering to obtain a filter cake with glycyrrhiza polysaccharide and an ethanol extract with glycyrrhizic acid, and mono-ammonium glycyrrhizinate is obtained from the extracted solution; reflux extraction and filtering are carried out on the solid phase obtained through complexing separation at preset temperature by means of acid alcohol, vacuum concentration is carried out on filtered clear liquid, and glycyrrhiza uralensis is obtained.

Description

Technical field [0001] The invention relates to the technical field of separation and extraction of licorice components, in particular to a method for continuous high-pressure comprehensive extraction of licorice components. Background technique [0002] Licorice ranks first in the 100 medicines in the field of Chinese medicine and is one of the most widely used varieties of natural medicinal materials. my country is a major producer of licorice and a major exporter of licorice. Most domestic pharmaceutical factories use licorice pieces and extracts. In international trade, primary products such as decoction pieces, extracts, and crude glycyrrhizic acid are exported. The products with high technical content are about 75% (HPLC method) of monoammonium glycyrrhizinate, but these products are not of high added value. Therefore, it is a very urgent task to speed up the improvement of the high value-added deep processing technology of my country's licorice industry and change the struc...

AI Technical Summary

Problems solved by technology

[0007] Through the research of the searched literature and papers, it is found that they have a common deficiency, that is, they cannot be mass-produced by ultra-high pressure methods. The main reasons are: a. The amount of each experiment is very small (10g~ 100g); b. Use organic solvents (such as ethanol) as extraction solvents; c. Intermittent operation, no continuity in the primary extraction process; d. All separation and removal of impurities are performed in organic solvents

These deficiencies strictly limit the feasibility of the application of ultra-high pressure technology in industrial scale production

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