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Labdane-type diterpene compound and its preparation method and use

A technology of compounds and diterpenes, applied in the application field in the preparation of antitumor drugs, can solve the problems of few components and activities, etc.

Inactive Publication Date: 2015-09-30
HENAN LUOYANG BONESETTING MEDICINE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the wide variety of configurations of terpenoids, different methods can obtain different compounds, and there are few studies on the components and activities. The active ingredient of the drug has not been reported

Method used

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  • Labdane-type diterpene compound and its preparation method and use
  • Labdane-type diterpene compound and its preparation method and use
  • Labdane-type diterpene compound and its preparation method and use

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Embodiment Construction

[0023] The preparation method of the helianthene type diterpene compound of the present invention

[0024] Take 5 kg of dry powder of motherwort aerial parts (purchased from Shanghai Kangqiao Chinese Medicine Decoction Pieces Co., Ltd., place of origin Anhui), and use percolation method at room temperature to extract 3 times with petroleum ether to degrease, each volume is 15 L; the dregs are extracted with 95% ethanol for 3 times, each volume 15L, combined ethanol extracts, recovered under reduced pressure, to obtain 280g of ethanol extract. The extract was dissolved in 300ml of a mixed solvent of dichloromethane and methanol (1:1, V / V), mixed with silica gel to mix the sample (500g, 200-300 mesh), and the evenly mixed silica gel was obtained after evaporating the solvent. Use 200-300 mesh silica gel (1500g) to pack the column and separate the mixed sample silica gel. Elute with n-hexane-ethyl acetate gradient (10:1, 4:1, 2:1, 1:1, 1:4, 0:1, V / V). Collect the fraction elu...

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Abstract

The invention discloses a labdane-type diterpene compound. The labdane-type diterpene compound has a chemical structure shown in the following description. The invention relates to the field of natural drugs and concretely relates to the novel labdane-type diterpene compound in motherwort, a preparation method of the compound and a medical use of the compound in preparation of antitumor drugs. An external test proves that the novel labdane-type diterpene compound has effects of resisting cervical carcinoma, leukemia and breast cancer and can be used for preparing drugs for resisting cervical carcinoma, leukemia and breast cancer.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to a new helianthin-type diterpene compound, a preparation method and the application of the compound in the preparation of antitumor drugs. Background technique [0002] Helenoid diterpenes are bicyclic diterpenes, with decahydronaphthalene as the core, including its demethylation, secondary cleavage and rearrangement compounds, and is a class of diterpenes with richer structural types. The most representative helianthin-type diterpenes are from Andrographis paniculata ( Andrographis panis ) and andrographolide (Andrographolide) isolated from Coleus forskohlii ( Coleus forskohlii ) obtained in Coleus (Forskolin). The former has good antibacterial and anti-inflammatory effects, and the latter can be used to strengthen the heart, antidepressant, relieve spasm and treat asthma. In recent years, a large number of new helianthane-type diterpenes have been discovered with rich struct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/94A61P35/00A61P35/02
CPCC07D307/94
Inventor 孙实赵新杰武爱玲王一方张宏都郭畅丁震
Owner HENAN LUOYANG BONESETTING MEDICINE SCI & TECH
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