Absorbable biliary duct stent and preparation method thereof

Abstract

The invention relates to an absorbable biliary duct stent which comprises a stent body and a medicine layer coating the surface of the stent body. The stent body is provided with a tubular fine metal mesh structure, the fine metal mesh structure comprises a plurality of annular supporting rings and connectors for connecting the annular supporting rings, two adjacent annular supporting rings are connected through one connector, pipes made of absorbable high polymer materials are engraved by laser to form the stent body with the fine metal mesh structure, a plurality of basic units similar to sinusoidal waveforms are connected to form each annular supporting ring, two adjacent connectors are crossly arranged at intervals, the connectors are linear connecting rods axially arranged along the stent, and the medicine layer contains biliary tumor resistant medicines and / or biliary calculus resistant medicines. The invention further provides a preparation method for manufacturing the absorbable biliary duct stent. The biliary duct stent has internal degradability, fine expansion coefficient and radial mechanical support capacity, and the medicine layer coating the surface of the stent can treat benign and malignant biliary hyperplasia stenosis and avoid aggravating biliary obstruction due to biliary hyperplasia restenosis after stent implantation.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a biliary stent and a preparation method thereof. Background technique [0002] Implantation of biliary stents is a good method for the clinical treatment of biliary stricture or obstruction. In the process of complex biliary reconstruction, biliary stents can not only play a role in decompression, support, drainage, and facilitate biliary healing, but also facilitate the observation of bile status and Postoperative cholangiography and other effects. [0003] An ideal biliary stent should be degraded into a harmless monomer in the body after completing the supporting and repairing functions and then excreted from the body. However, a major disadvantage of the non-degradable metal stents currently used clinically is that the permanent placement of the stents is likely to cause inflammation. The degradable metal stents (Ni, Ti, Mg and other metals and alloys) c...

AI Technical Summary

Problems solved by technology

However, a major disadvantage of the non-degradable metal stents currently used clinically is that the permanent placement of the stents is likely to cause inflammation. The degradable metal stents (Ni, Ti, Mg and other metals and alloys) currently in the research stage A large amount of metal ions will be released during the process, which will cause certain harm to the body.

In addition, currently reported biliary stents processed by polymer materials are braided fibers, which have poor expansion coefficients and mechanical properties, and their applications are limited.

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