Microscale fibre-optical probe as well as method and device for detecting content of glucose

Abstract

The invention discloses a microscale fibre-optical probe as well as a method and a device for detecting content of glucose. A micro-nanofiber of which the surface is modified by glucose oxidase (GOD) is taken as a probe. A measurement principle is as follows: when light waves are transmitted in the micro-nanofiber probe, evanescent waves exist outside the micro-nanofiber, is transmitted along the axial direction of the micro-nanofiber, and interacts with the environment outside the micro-nanofiber. Glucose is converted into gluconic acid under catalytic action of glucose oxidase modifying the surface of the micro-nanofiber, the micro-nanofiber causes change of the refractive index of the environment, so that the evanescent waves have phase modulation during transmission in the area and therefore change of the equivalent optical path of the micro-nanofiber is caused. By measuring the change information of optical path caused by change of the concentration of glucose, the content of the glucose is measured. The microscale fibre-optical probe as well as the method and the device have the advantages that the sensitivity and response speed are very high, the measurement range is wide, and the reliability is high, and application requirements in the fields including food safety, disease surveillance, clinical care and the like can be met.

Description

technical field [0001] The invention relates to the technical field of biochemical sensing, in particular to a microscale optical fiber probe, a glucose content detection method and a device. Background technique [0002] In daily life, it is of great significance to obtain the content information of glucose. Blood sugar is the main substance that provides energy to the human body. The detection of blood sugar concentration in the human body is very important in the clinical detection of biomedicine, because both high and low blood sugar reflect problems in human metabolism. In clinical treatment, glucose solution is often used as injection therapy to directly provide supplies and energy for patients who have difficulty eating. In industrial applications, glucose is used in large quantities as a reducing agent. Therefore, the detection of glucose is a technology with practical application significance. [0003] At present, the application of fiber optic sensors in biochem...

AI Technical Summary

Problems solved by technology

However, the use of special grating technology to realize biochemical sensing has a large size and low sensitivity, and the requirements for the resolution of the instrument used for detection are very high, which makes the use cost of this technology relatively high. In addition, the grating is used for a long time There are also problems with reliability under

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