Fluorine benzene ruthenium compound and preparation method and application thereof

A fluorobenzene ruthenium compound and a ruthenium compound technology are applied in the field of ruthenium compound preparation, and achieve the effects of easy availability of raw materials, simple preparation method and strong inhibitory activity

Inactive Publication Date: 2015-08-19
THE SIXTH CONSTR CO LTD OF CHINA NAT CHEM ENG
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, dozens of anti-tumor drugs currently used in clinical chemotherapy or a

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fluorine benzene ruthenium compound and preparation method and application thereof
  • Fluorine benzene ruthenium compound and preparation method and application thereof
  • Fluorine benzene ruthenium compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A fluorobenzeneruthenium compound, the fluorobenzeneruthenium compound has the structure of (I):

[0027]

[0028] A preparation method of a fluorobenzene ruthenium compound, comprising the following steps:

[0029] Step 1. Dissolve 1 g of hydrated ruthenium trichloride and 30 mL of γ-terpinene in 70 mL of dehydrated ethanol, heat under reflux for 6 hours, and stand to separate out to obtain dichloro-di-methylisopropyl dichloride. diruthenium benzene;

[0030] Step 2: Weigh 8g of difluorobenzenesalicylic acid and dissolve it in 40mL of solvent, add 4g of N,N-dimethylformamide as a catalyst, then add substituted phenylacetyl chloride, react at 65°C for 8 hours, remove After the solvent, phenylacetyl fluorobenzene salicylic acid is obtained;

[0031] Step 3. Dissolve 1g of dichloro-di-methylisopropylbenzenediruthenium dichloride and 3g of phenylacetylfluorobenzenesalicylic acid in 80mL of tetrahydrofuran, react at 65°C for 6 hours, and purify, That's it.

[0032] W...

Embodiment 2

[0037] A preparation method of a fluorobenzene ruthenium compound, comprising the following steps:.

[0038] Step 1. Dissolve 6g of hydrated ruthenium trichloride and 80mL of γ-terpinene in 200mL of dehydrated ethanol, heat under reflux for 6 hours, and stand to separate out to obtain dichloro-di-methylisopropyl dichloride. diruthenium benzene.

[0039] Step 2: Weigh 12g of difluorobenzenesalicylic acid and dissolve it in 80mL of solvent, add 8g of N,N-dimethylformamide as a catalyst, then add substituted phenylacetyl chloride, react at 75°C for 12 hours, remove After solvent, phenylacetylfluorobenzenesalicylic acid is obtained.

[0040] Step 3. Dissolve 3g of dichloro-di-methylisopropylbenzene diruthenium dichloride and 9g of phenylacetylfluorobenzenesalicylic acid in 100mL of tetrahydrofuran, react at 75°C for 10 hours, and purify, That's it.

[0041] Wherein, the hydrated ruthenium trichloride in the first step is hydrated ruthenium trichloride with a ruthenium weight co...

Embodiment 3

[0046] A preparation method of a fluorobenzene ruthenium compound, comprising the following steps:.

[0047] Step 1. Dissolve 3g of hydrated ruthenium trichloride and 60mL of γ-terpinene in 120mL of absolute ethanol, heat under reflux for 6 hours, and stand to separate out to obtain dichloro-di-methylisopropyl dichloride. diruthenium benzene;

[0048] Step 2: Weigh 10g of difluorobenzenesalicylic acid and dissolve it in 60mL of solvent, add 6g of N,N-dimethylformamide as a catalyst, then add substituted phenylacetyl chloride, react at 70°C for 10 hours, remove After the solvent, phenylacetyl fluorobenzene salicylic acid is obtained;

[0049] Step 3. Dissolve 2g of dichloro-di-methylisopropylbenzenediruthenium dichloride and 6g of phenylacetylfluorobenzenesalicylic acid in 90mL of tetrahydrofuran, react at 70°C for 8 hours, and purify, That's it.

[0050] Wherein, the hydrated ruthenium trichloride in the first step is hydrated ruthenium trichloride with a ruthenium weight con...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention provides a fluorine benzene ruthenium compound and a preparation method and application thereof. The structure of the fluorine benzene ruthenium compound is shown in formula (I). The fluorine benzene ruthenium compound is synthesized and generated by dichloridized dichloro-2-methyl-isopropyl-benzo dirhodium and phenylacetyl diflunisal and shows a relatively strong inhibition activity on a human lymph cancer cell strain and a liver cancer strain of a human body. The fluorine benzene ruthenium compound can be used for preparing medicines for treating liver cancer and lymph cancer, and can be prepared to injections, tablets, pellets, capsules, suspensions or emulsions. The fluorine benzene ruthenium compound provided by the invention can improve the lipid solubility and the permeability of medicines, enhances the dissolubility of a biological film and prompts the speed of absorption and transmission in vivo, so that the physiological action changes.

Description

technical field [0001] The present invention relates to the field of preparation of a ruthenium compound, more particularly, the present invention relates to a ruthenium fluorobenzene compound and a preparation method and application thereof. Background technique [0002] Liver cancer refers to malignant tumors that occur in the liver, including primary liver cancer and metastatic liver cancer. People often say liver cancer refers to primary liver cancer. Primary liver cancer is one of the most common malignant tumors in clinic. According to the latest statistics, there are about 600,000 new liver cancer patients in the world every year, ranking fifth among malignant tumors. Primary liver cancer can be divided into hepatocellular carcinoma, cholangiocarcinoma and mixed hepatocellular carcinoma according to cell type. [0003] Possible causes of lymphoma include a deficiency of the immune system, viral infection, use of radiation or drugs, and genetics. Studies have shown t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07F15/00A61K31/28A61K31/616A61P35/00
CPCC07F15/0053
Inventor 张浩肖晓阳
Owner THE SIXTH CONSTR CO LTD OF CHINA NAT CHEM ENG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap