A traditional Chinese medicine composition for treating liver fibrosis and its preparation method and application

Abstract

The invention discloses a traditional Chinese medicine composition for treating liver fibrosis, a preparation method and an application thereof, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition of the present invention is composed of the following raw materials in parts by weight: 10-20 parts of Bean root, 5-15 parts of Araceae, and 10-20 parts of Tongtiancao. The results of pharmacological experiments show that the traditional Chinese medicine composition of the present invention can improve the content levels of serum biochemical indicators ALT, AST and AKP in Kunming mice with hepatic fibrosis, improve the content level of Hyp in liver tissue, and improve the spleen, liver and thymus of the mouse model of hepatic fibrosis. Improve the content of HA, LN, PCIII, and CⅣ in mouse models of liver fibrosis, improve the expression levels of TGF-β1, RLX, and TIMP-1 proteins in liver tissue of liver fibrosis, and improve the ultrastructure of liver tissue of liver fibrosis , and had no significant effect on the body weight of mice. Thus it can be seen that the traditional Chinese medicine composition of the present invention has obvious therapeutic effect on liver fibrosis without side effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating liver fibrosis and its preparation method and application, belonging to the field of traditional Chinese medicine. Background technique [0002] Hepatic fibrosis is when the hepatocytes in the liver undergo necrosis and inflammatory stimulation, the proliferation and degradation of extracellular matrix such as collagen between liver cells are out of balance, manifested as excessive collagen hyperplasia or decreased collagen degradation, In turn, it leads to the pathological process of abnormal deposition of fibrous connective tissue between hepatocytes and liver lobules in the liver. A small amount of collagen deposition is called liver fibrosis. A large amount of collagen deposition is accompanied by structural remodeling of liver lobules and formation of pseudolobules. And the formation of special nodules can g...

AI Technical Summary

Problems solved by technology

[0007] There are many types of drugs for the treatment of liver fibrosis, including TNF-α antagonists, cyclooxygenase inhibitors, antioxidants, TGF-β1 antagonists, drugs that inhibit TIMP activity, anti-fibrosis therapy, etc., but these drugs often have side effects , affecting the health of the body

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