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Traditional Chinese medicine preparation for preventing chronic hepatitis B YMDD (tyrosine, methionine, d-aspartic acid, d-aspartic acid) mutation

A technology for chronic hepatitis B and traditional Chinese medicine preparations, applied in the directions of medical preparations containing active ingredients, antiviral agents, drug combinations, etc.

Inactive Publication Date: 2015-07-22
王新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no ideal drug in clinical practice to prevent the generation of lamivudine YMDD variants

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Weigh 20g of phoenix crown grass, 25g of fiery mother grass, 35g of centipede, 12g of Phnom Penh rabbit ears, 6g of frightening wind grass, 25g of abacus root, 45g of red iron thorn, 6g of rock green orchid, and 20g of red back leaf , Canna root 6g, Xihuangcao 20g, decoct the above-mentioned traditional Chinese medicine in water to make a decoction.

Embodiment 2

[0015] Example 2: Weighing 25g of Pteris chinensis, 30g of motherwort, 40g of centipede, 15g of Phnom Penh rabbit ears, 9g of frightening wind grass, 30g of abacus root, 50g of red iron thorn, 9g of rock green orchid, and 25g of red back leaf , Canna root 9g, Xihuangcao 25g, decoct the above-mentioned traditional Chinese medicine in water to make a decoction.

Embodiment 3

[0016] Example 3: Weighing 15g of Pteris vulgaris, 20g of Motherwort, 30g of Centipede Xiangtian, 9g of Phnom Penh Rabbit Ear, 3g of Frightweed, 20g of Abacus Root, 40g of Red Iron Bubble Thorn, 3g of Rock Green Orchid, and 15g of Redback Leaf , Canna root 3g, Xihuangcao 15g, decoct the above-mentioned traditional Chinese medicine in water to make a decoction.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine preparation for preventing chronic hepatitis B YMDD (tyrosine, methionine, d-aspartic acid, d-aspartic acid) mutation. According to traditional Chinese medicine, the etiology and pathogenesis of chronic hepatitis B are complicated, a patient is infected with damp-heat epidemic toxin, so that damp toxin accumulation, qi-stagnation and blood stasis and insufficient anti-pathogenic energy are caused and can cause the chronic hepatitis B. Traditional Chinese medicines comprising herb of sword brake, Chinese knotweed, roots of common sesbania, frangrant ainsliaea herb, all-grass of straightstalk alpine meadowrue, roots of puberulous glochidion herb, multibract raspberry roots, herb of rupestrine dragonhead, roots or leaves of redback christmashush, roots of canna indica and rabdosia serra are selected and decocted to decoction with water. Clinical tests show that the curative effect is remarkable.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine preparation for preventing YMDD variation of chronic hepatitis B. Background technique [0002] After the nucleoside analogue lamivudine binds to HBV polymerase in the form of triphosphorylation in vivo, it competes to inhibit the activity of the polymerase, resulting in the termination of HBV DNA chain synthesis. HBVDNA concentration. However, the tyrosine, methionine, aspartate, and aspartate (YMDD) motifs of the HBV DNA polymerase domain C can be mutated after treatment with lamivudine, resulting in HBV evading the effect of lamivudine and developing resistance. Drug strains, so that the clinical efficacy of lamivudine decreased. It is generally believed that the occurrence of YMDD mutations is more common after half a year of treatment with lamivudine, and the YMDD mutation rate is about 25% after 52 weeks of treatment. However, r...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P1/16A61P31/20A61P43/00
Inventor 王新
Owner 王新
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