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Anti-rheumatoid arthritis drug gel containing paclitaxel liposome and preparation method of gel

A rheumatoid and paclitaxel technology, applied in anti-inflammatory agents, drug combinations, pharmaceutical formulations, etc., can solve problems such as easy aggregation, poor stability of liposome properties, and difficulty in long-term storage, so as to improve bioavailability and relieve pain Effect

Inactive Publication Date: 2015-06-10
黄萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stability of liposome properties is poor, and it is prone to aggregation, fusion and leakage of encapsulated drugs during storage, making it difficult to store for a long time

Method used

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  • Anti-rheumatoid arthritis drug gel containing paclitaxel liposome and preparation method of gel
  • Anti-rheumatoid arthritis drug gel containing paclitaxel liposome and preparation method of gel
  • Anti-rheumatoid arthritis drug gel containing paclitaxel liposome and preparation method of gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Preparation of paclitaxel liposomes:

[0028] prescription:

[0029] Process: Dissolve 0.15g paclitaxel, 1.8g soy lecithin, 0.8g cholesterol, and vitamin E into chloroform according to a certain proportion, put it in a pear-shaped bottle, slowly rotate and evaporate under reduced pressure on a rotary evaporator at 45℃, and pass in Nitrogen removes the organic solvent, so that the lipid film is evenly distributed on the flask. Mix 20 mL of the sucrose solution with the membrane for hydration for 30 minutes, and ultrasonically vibrate to obtain a white suspension, which is sheared 4 times with a high-pressure micro-jet nano-disperser with a power of 9 Kpsi to obtain a paclitaxel nano-liposome solution. Pre-freeze for 5h and freeze-dry.

Embodiment 2

[0030] Example 2: Preparation of paclitaxel liposomes:

[0031] prescription:

[0032] Process: Dissolve 0.1g of paclitaxel, 5.7g of soy lecithin, 0.5g of cholesterol, and appropriate amount of vitamin E in chloroform according to a certain ratio, place in a pear-shaped bottle, slowly rotate and evaporate under reduced pressure on a rotary evaporator at 45°C, pass in Nitrogen removes the organic solvent, so that the lipid film is evenly distributed on the flask. Mix 20 mL of the sucrose solution with the membrane for hydration for 30 minutes, and ultrasonically vibrate to obtain a white suspension, which is sheared 4 times with a high-pressure micro-jet nano-disperser with a power of 9 Kpsi to obtain a paclitaxel nano-liposome solution. Pre-freeze for 5h and freeze-dry.

Embodiment 3

[0033] Example 3: Preparation of paclitaxel liposomes:

[0034] prescription:

[0035] Process: Dissolve 0.06g of paclitaxel, 4.5g of soybean lecithin, 0.5g of cholesterol, and appropriate amount of vitamin E in chloroform according to a certain ratio, place in a pear-shaped bottle, slowly rotate and evaporate under reduced pressure on a rotary evaporator at 45℃, and pass in Nitrogen removes the organic solvent, so that the lipid film is evenly distributed on the flask. Mix 20 mL of the sucrose solution with the membrane for hydration for 30 minutes, and ultrasonically vibrate to obtain a white suspension, which is sheared 4 times with a high-pressure micro-jet nano-disperser with a power of 9 Kpsi to obtain a paclitaxel nano-liposome solution. Pre-freeze for 5h and freeze-dry.

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Abstract

The invention relates to anti-rheumatoid arthritis drug gel containing paclitaxel liposome and a preparation method of the gel. The gel is prepared from main drugs and blank gel, wherein the main drugs comprise paclitaxel liposome and lidocaine hydrochloride; the mass volume ratio of the paclitaxel liposome to lidocaine hydrochloride is 5:100-20:100; and the mass volume ratio of lidocaine hydrochloride to the blank gel is 1:100-5:100. According to the requirements of evidence-based medicine, a drug paclitaxel for treating RA and lidocaine are compatible with each other, the paclitaxel is coated by utilizing a liposome technology, the bioavailability is improved, and the prepared gel suitable for directed use at an affected part is adopted. The gel achieves a treatment effect aiming at the pathogenesis of RA, and pain of a patient suffering from RA can be rapidly relieved. A novel therapy approach is provided for vast patients suffering from RA.

Description

Technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an anti-rheumatoid arthritis pharmaceutical gel containing paclitaxel liposomes and a preparation method thereof. Background technique [0002] Rheumatoid arthritis (RA) is an autoimmune disease with unclear pathogenesis. It is characterized by chronic progressive joint destruction, which is mainly manifested by high proliferation of synovial lining cells, massive infiltration of interstitial inflammatory cells, and The formation of microvessels and pannus. It is characterized by multiple joints, symmetry, and aggressive joint inflammation of the small joints of the hands and feet, and can involve internal organs. [0003] For rheumatoid arthritis, there is currently no specific medicine. The existing treatments can only be symptomatic treatment, focusing on improving the condition, such as reducing the inflammation of the joints, inhibiting the development of the disease and...

Claims

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Application Information

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IPC IPC(8): A61K31/337A61K9/06A61K47/24A61P29/00A61P19/02A61K31/167
Inventor 黄萍杨秀丽羊波李承乐戴纯辉
Owner 黄萍
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