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Aqueous liquid medicine

A liquid and water-based technology, applied in drug combination, sensory disease, drug delivery, etc., to achieve the effects of eliminating discomfort, improving retention, and inhibiting viscosity reduction

Active Publication Date: 2015-05-27
SENJU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] On the other hand, in the past, it has been reported that nonionic surfactants become the main cause of the viscosity reduction of aqueous liquid preparations containing cellulose-based viscous agents (see paragraph 0005 of Patent Document 3, etc.), and according to the prior art, nonionic surfactants Active surfactants are considered to promote the decrease in viscosity over time rather than inhibiting the decrease in viscosity over time of aqueous liquid preparations containing hypromellose and / or hydroxyethyl cellulose. The above is the current status

Method used

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Embodiment

[0087] Hereinafter, examples are given and the present invention will be specifically described, but the present invention is not limited by these contents.

[0088] Among them, in the following examples and comparative examples, hypromellose was used under the trade name "METOLOSE 65SH-4000" (substitution degree type 2906, weight average molecular weight 350,000, manufactured by Shin-Etsu Chemical Co., Ltd.), hydroxyethyl cellulose The product name "NATROSOL 250M PHARM" (weight average molecular weight 720,000, Ashland Industries) was used for the element, the product name "HPC-H" (manufactured by Nippon Soda Co., Ltd.) was used for the hydroxypropyl cellulose, and the product name "Natrosol" was used for sodium carboxymethyl cellulose. The name "Serogen PR-S Nikki" (manufactured by Daiichi Kogyo Pharmaceutical Co., Ltd.), the trade name "Alginic Acid" (manufactured by KIMICA Co., Ltd.) for alginic acid, and the trade name "Eko-Gam T" (DSP GOKYO food & chemical Co., Ltd.) for ...

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Abstract

The purpose of the present invention is to provide formulation technology with which it is possible to prevent a reduction over time in the kinematic viscosity of an aqueous liquid medicine containing hypromellose and / or hydroxyethyl cellulose. It is possible to prevent a reduction over time in the viscosity of an aqueous liquid medicine compounded by combining hypromellose and / or hydroxyethyl cellulose and polyoxyethylene-hydrogenated castor oil and / or polyoxyl stearate.

Description

technical field [0001] The present invention relates to an aqueous solution containing hypromellose and / or hydroxyethylcellulose and capable of suppressing a decrease in viscosity over time. Background technique [0002] Conventionally, it is known that water-based liquid preparations such as eye drops and nasal drops are given viscosity by blending a cellulose-based viscous agent in order to improve the feeling of use, maintain a moist feeling, a refreshing feeling, and maintain drug retention. Various aqueous liquid preparations compounded with cellulose-based viscous agents have been put into practical use today, such as improvement of cellulose, enhancement of drug efficacy, etc. (refer to Patent Document 1). [0003] However, when a cellulose-based viscous agent such as hypromellose or hydroxyethyl cellulose is mixed with an aqueous liquid preparation, there is a problem that the viscosity stability is low and the viscosity of the liquid preparation decreases over time....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K9/08A61K47/10A61K47/34A61P27/02
CPCA61K9/08A61K47/10A61K47/34A61K47/38A61P27/02A61P27/04
Inventor 中村律子
Owner SENJU PHARMA CO LTD
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