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Preparation method of traditional Chinese medicine composition capable of diminishing inflammation and relieving pain

An anti-inflammatory and analgesic and composition technology, applied in the field of pharmaceutical preparations, can solve the problems such as difficulty in obtaining international recognition for the anti-inflammatory and analgesic efficacy of traditional Chinese medicine, untimely tracking, and improper selection of animal models.

Inactive Publication Date: 2015-05-06
GANSU PROVINCIAL HOSPITAL OF TCM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are two problems. On the one hand, due to the complexity of multiple factors such as TCM syndromes and prescriptions, clinical observation and clinical trials are limited to low-level repetition, and there is a lack of well-designed large multi-center, randomized, double-blind, placebo-controlled trials. However, the objective evidence of systematic review is mainly based on "empirical medicine" methods, so the anti-inflammatory and analgesic efficacy of traditional Chinese medicine has been difficult to be recognized internationally.
On the other hand, in the basic research of analgesic traditional Chinese medicine, due to the lack of timely follow-up of the international research on the mechanism of clinical pathological pain, when screening new analgesic drugs, it is still impossible to recognize the difference between "physiological pain" and "pathological pain". Due to the differences in the pathogenesis of "pain" and the diversity of mechanisms in the process of pathological pain and its continuous chronicity, it is often difficult to choose an animal model properly, which leads to the inability to correctly evaluate the efficacy of the drug, and also makes it difficult to study the site of action and mechanism of the drug. Going deeper, this seriously hinders the research and development of analgesic traditional Chinese medicine

Method used

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  • Preparation method of traditional Chinese medicine composition capable of diminishing inflammation and relieving pain
  • Preparation method of traditional Chinese medicine composition capable of diminishing inflammation and relieving pain
  • Preparation method of traditional Chinese medicine composition capable of diminishing inflammation and relieving pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] (1) Mix the 6 medicinal materials of peach kernel, safflower, red peony root, eupatorium, licorice, and leech, add water whose weight ratio is 8 times that of the mixed medicinal materials, extract 3 times, each time for 1 hour, filter, and combine the filtrates, Concentrate in a water bath, then add ethanol with a concentration of 95% in an amount twice the weight of the filtrate, let it stand for 16 hours, filter, and retain the alcohol solution for future use.

[0064] (2) Mix the 4 medicinal materials of angelica, woody, green bark and chuanxiong, add water with a weight ratio of 10 times that of the mixed medicinal materials, heat and extract the volatile oil for 6 hours, collect the volatile oil and keep it for use; In the final water liquid, add ethanol with a weight ratio of 2 times that of the filtrate and a concentration of 95%, let it stand for 16 hours, filter, and retain the alcohol liquid for use;

[0065] (3) Mix the medicinal dregs described in the above...

Embodiment 2

[0068] (1) Mix the 6 medicinal materials of peach kernel, safflower, red peony root, eupatorium, licorice, and leech, add water whose weight ratio is 12 times that of the mixed medicinal materials, extract once, 2 hours each time, filter, and combine the filtrates, Concentrate in a water bath, then add ethanol with a concentration of 70% and 5 times the weight ratio of the filtrate, let it stand for 12 hours, filter, and retain the alcohol solution for future use.

[0069] (2) Mix the 4 medicinal materials of angelica, woody, green bark and chuanxiong, add water with a weight ratio of 6 times that of the mixed medicinal materials, heat and extract the volatile oil for 2 hours, collect the volatile oil and keep it for use; In the final aqueous solution, add ethanol with a weight ratio of 1.5 times and a concentration of 80% of the filtrate, let it stand for 24 hours, filter, and retain the alcohol solution;

[0070] (3) Mix the medicinal residues described in the above step (2)...

Embodiment 3

[0073] (1) Mix the 6 medicinal materials of peach kernel, safflower, red peony root, eupatorium, licorice, and leech, add water with a weight ratio of 6 times that of the mixed medicinal materials, extract twice, each time for 0.5h, filter, and combine the filtrates , concentrated in a water bath, and then added ethanol with a weight ratio of 1.5 times that of the filtrate and a concentration of 80%, let it stand for 24 hours, filtered, and retained the alcohol solution for use.

[0074] (2) Mix the 4 medicinal materials of Angelica sinensis, Muxiang, Qingpi, and Chuanxiong, add water with a weight ratio of 12 times that of the mixed medicinal materials, heat and extract the volatile oil, the extraction time is 8 hours, and collect the volatile oil for later use; In the final water liquid, add the ethanol that is 5 times of the weight ratio of the filtrate and the concentration is 70%, let it stand for 12 hours, filter, and retain the alcohol liquid;

[0075] (3) Mix the medic...

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Abstract

The invention relates to a preparation method of a traditional Chinese medicine composition capable of diminishing inflammation and relieving pain. The traditional Chinese medicine composition is composed of following medicinal ingredients, by weight, peach kernel, safflower carthamus, radix paeoniae rubra, herba lycopi, liquorice, leech, angelica sinensis, radix aucklandiae, pericarpium citri reticulatae viride, ligusticum wallichii, radix rehmanniae recen, and pseudo-ginseng. The preparation method is simple, scientific, and convenient for operation; and granule and capsule preparations can be prepared finally.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition with anti-inflammatory and analgesic effects, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Bacterial infectious diseases are a problem that the medical field will always face. The invention of western medicine antibacterial drugs is an epoch-making sign for the treatment of bacterial infectious diseases. Huge damage has become an indisputable fact at present, and even the damage caused by it is far greater than the positive effect it brings. The understanding of anti-inflammatory and analgesic in traditional Chinese medicine and the formation of principles, methods, prescriptions and medicines have a long history. However, there are two problems. On the one hand, due to the complexity of multiple factors such as TCM syndromes and prescriptions, clinical observation and clinical trials are limited to low-level ...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P29/00A61K35/62
Inventor 李盛华杜茂波谢兴文刘淑芝姜华
Owner GANSU PROVINCIAL HOSPITAL OF TCM
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