Application of Bupleurum Chinese and Shenmai on aspect of preparation of drugs for preventing and treating ionization radiation injuries

Abstract

The invention relates to the field of medicines, discloses the application of Bupleurum Chinese and Shenmai on the aspect of preparation of a medicine for preventing and treating ionization radiation injuries, and particularly discloses the application of the combination of the two pure traditional Chinese preparations of a total extract of Bupleurum Chinese or Bupleurum scorzonerifolium and a red ginseng and radix ophiopogonis extract (a Shenmai injection) on the aspect of preparation of the medicine for preventing and treating ionization radiation injuries. According to the application, the extract of Bupleurum Chinese and the Shenmai injection play the radiation protection role on the cell level and the animal living body level, the protective effect is achieved within the wide dosage range of the lethal dosage, sub-lethal dosage and low dosage radiation, the combination of the two medicines is better than independent use of the medicines, and the application is low in combination cost, has extensive sources, and can be used for preparing the medicine for preventing and treating related injuries caused by ionization radiation and treating diseases.

Description

Involved areas The invention relates to the field of medicine, in particular, the active ingredients extracted from Bupleurum chinensis or Bupleurum angustifolia and the pure traditional Chinese medicine preparation extracted from red ginseng and Radix Ophiopogon japonicus are used for preventing and treating the disease caused by ionizing radiation. Related injury treatment and disease treatment applications. Background technique With the vigorous development of the global nuclear industry, nuclear technology has been widely used in various fields such as nuclear power plants, aerospace industry, national defense, and biomedicine. The hidden dangers of nuclear war and nuclear terrorism, the protection and treatment of body damage caused by ionizing radiation (referred to as radiation damage) are receiving more and more attention. On the other hand, the incidence of malignant tumors and the number of patients have been on the rise in recent years. Radiation therapy, as on...

AI Technical Summary

Problems solved by technology

Drugs related to the treatment of radiation damage currently on the market mainly include: sulfur-containing compounds, hormones, cytokines, and Chinese herbal medicines, etc., which have their own inherent defects: for example, sulfur-containing compounds generally have relatively large side effects, and amifostine (also known as Amifostine ) as a representative of this type of compound is currently recognized as the compound with the best protective effect, and is the first selective broad-spectrum cytoprotective agent approved by the international regulatory agency, but the half-life is extremely short (7 minutes) and expensive (domestic The medical market price is 400-500 yuan / branch) which limits its application; while the prevention and treatment of hormonal drugs to radiation damage is mainly to bone marrow nucleated cells, hematopoietic stem cells and progenitor cells, and the impact of such drugs on sexual organs and reproductive system It limits its wide use; cytokine drugs such as interleukins and colony-stimulating factor drugs can alleviate and treat the damage to the bone marrow hematopoietic function system caused by radiation, but its radiation protection effect is closely related to the time of administration (used for prevention and In the medical practice of rescue and treatment, such drugs require high levels of medical testing and attention), have obvious inflammatory effects, are expensive, and are difficult to store at room temperature; anti-radiation components of Chinese herbal medicines mainly include phenols, polysaccharides, natural Flavonoids have the characteristics of unclear active ingredients and low toxicity. After years of research, there are no similar drugs on the market or to be listed

So far, Bupleurum extract, Shenmai injection, and the composition of the two have not been reported in the preparation of drugs for the prevention and treatment of ionizing radiation damage and tumor radiotherapy

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