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Compound vitamin injection medicine composition and preparation method

A technology for compound vitamins and compositions, applied in the directions of drug combinations, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve the problems of high concentration of vitamin B2, inability to guarantee product quality, and time-consuming, etc., and improve wettability. , the effect of shortening the preparation time and improving the efficiency

Active Publication Date: 2015-04-22
北京柏雅联合药物研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The active ingredient riboflavin sodium phosphate (vitamin B2) in this product is an orange-yellow crystalline powder. Although it dissolves in water, the dissolution rate is very slow and the wettability is poor. If the riboflavin sodium phosphate is directly mixed with When water contacts and dissolves, there will be agglomeration and aggregation. The aggregated agglomerates will not be able to contact water due to their poor wettability. Even if they are vigorously stirred, they still cannot be resolved. This operation will not only cause excessive local concentration of vitamin B2, but also uneven content. , and it takes a lot of time to dissolve, the quality of the product cannot be guaranteed, the operation is difficult in production, and the production efficiency is reduced

Method used

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  • Compound vitamin injection medicine composition and preparation method
  • Compound vitamin injection medicine composition and preparation method
  • Compound vitamin injection medicine composition and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Prescription:

[0030]

[0031]

[0032] 2. Production method

[0033] Weigh 200g of vitamin C and 94g of sodium bicarbonate and add them to 4000ml of water for injection and stir to dissolve; add 20g of citric acid, 25g of taurine, 10g of vitamin B1, stir to dissolve, to obtain solution A; 6.355g of Riboflavin sodium phosphate (5g based on riboflavin) was dispersed uniformly with 500ml 10% (w / v) propylene glycol aqueous solution (containing 50g propylene glycol) to obtain solution B; solution A and solution B were mixed to obtain solution C; Add 0.05% (w / v) of activated carbon for needles to C, stir for 30 minutes, filter, and then add 500ml of water for injection to a total of 5000ml; One preparation unit, seal it, and get it.

Embodiment 2

[0035] 1. Prescription:

[0036]

[0037] 2. Method of making:

[0038] Weigh 200g of vitamin C and mix with 85g of sodium bicarbonate, add to 2500ml of water for injection, stir to dissolve; add 20g of citric acid, 25g of taurine, 10g of vitamin B1, stir to dissolve to obtain solution A; 6.355g of sodium flavin phosphate (5g in terms of riboflavin) was uniformly dispersed with 500ml of 10% (w / v) propylene glycol aqueous solution (containing 50g of propylene glycol) to obtain solution B; solution A and solution B were mixed to obtain solution C; Add 0.05% (w / v) activated carbon for needles to solution C, stir for 30 minutes, filter, and then add 2000ml of water for injection to a total of 5000ml; One preparation unit, seal it, and get it.

Embodiment 3

[0040] 1. Prescription:

[0041]

[0042] 2. Method of making:

[0043] Weigh 200g of vitamin C and mix with 90g of sodium bicarbonate, add to 3000ml of water for injection, stir to dissolve; add 20g of citric acid, 25g of taurine, 10g of vitamin B1, stir to dissolve to obtain solution A; 6.355g of sodium flavin phosphate (5g in terms of riboflavin) was uniformly dispersed with 500ml of 10% (w / v) propylene glycol aqueous solution (containing 50g of propylene glycol) to obtain solution B; solution A and solution B were mixed to obtain solution C; Add 0.05% (w / v) activated carbon for needles to solution C, stir for 30 minutes, filter, and then add 1500ml water for injection to a total of 5000ml; One preparation unit, seal it, and get it.

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Abstract

The invention discloses a compound vitamin injection medicine composition and a preparation method, and belongs to the field of medicine manufacturing. According to the compound vitamin injection medicine composition, the active ingredients per dosage unit comprise 110 mg of vitamin B, 5 mg of riboflavin in riboflavin sodium phosphate and 200 mg of vitamin C. The compound vitamin injection medicine composition and the preparation method have the advantages that the PH is stable, the PH value is small in change, the content of main drugs is stable, related matter is less, the process is simplified, the liquid dosing time is shortened, and the operation difficulty is lowered.

Description

technical field [0001] The invention relates to a compound vitamin injection pharmaceutical composition and a preparation method, and belongs to the field of pharmacy. Background technique [0002] Compound vitamin injection is used for vitamin supplementation, that is, it is used when a large amount of vitamin supplementation is required and cannot be adequately ingested through food (such as wasting disease, pregnant women, breastfeeding women). Many diseases are accompanied by the lack of vitamin B1, vitamin B2, and vitamin C, and patients need to be supplemented with targeted supplements during treatment, such as neuralgia, neuritis, muscle atrophy, digestive organ disorders, oral organ inflammation, skin inflammation, and retinopathy. Wait. Patients who cannot adequately take vitamins through food in a short period of time need to be supplemented with necessary vitamins by means of parenteral nutrition by applying vitamin preparations during treatment. For example, pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/675A61K47/10A61P3/02A61K31/375A61K31/51
Inventor 李迪魏君朱霖
Owner 北京柏雅联合药物研究所有限公司
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