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Application of cordycepin in preparation of medicine for preventing and treating osteoporosis

A technology of osteoporosis and cordycepin, which is applied in the field of medicine, can solve the problems of no cordycepin, etc., achieve drug safety, promote bone formation, and prevent and treat osteoporosis

Inactive Publication Date: 2015-04-08
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In short, because of its unique biological activity, cordycepin may play a certain pharmacological role in various systems of the organism, but there is no relevant report or application of cordycepin in the skeletal system

Method used

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  • Application of cordycepin in preparation of medicine for preventing and treating osteoporosis
  • Application of cordycepin in preparation of medicine for preventing and treating osteoporosis
  • Application of cordycepin in preparation of medicine for preventing and treating osteoporosis

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Embodiment Construction

[0024] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings. For the experimental methods that do not specify specific conditions in the examples, usually follow the conventional conditions or the conditions suggested by the manufacturer.

[0025] RAW264.7 is a mouse mononuclear macrophage cell line that can differentiate into osteoclasts under the stimulation of receptor activator of nuclear factor kappa B ligand (RANKL) and human macrophage colony-stimulating factor (M-CSF). It is a commonly used cell model to study biological behaviors such as osteoclast differentiation, fusion, maturation, and osteophagy. At the same time, osteoclasts are closely related and coupled with osteoblasts, bone cells, and stromal cells, and are important regulatory elements for bone homeostasis and electrolyte homeostasis in the body. Osteoporosis is often caused by excessive bone resorption as a result of overactivatio...

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Abstract

The invention discloses application of cordycepin in the preparation of a medicine for preventing and treating osteoporosis. The cordycepin can inhibit the proliferation of osteoclast, the formation of multinuclear mature osteoclast, the bone resorption ability of osteoclast and the expression of osteoclast differentiation gene and can clear reactive oxygen species (ROS) in osteoclast, thus the physiological steady state of bone is stabilized, the bone loss is prevented, the bone density is kept, and a new medicine is provided to the prevention and treatment of osteoporosis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of cordycepin in the preparation of medicines for preventing and treating osteoporosis. Background technique [0002] Osteoporosis (osteoporosis, OP) is a systemic, progressive bone disease marked by systemic bone mass loss and bone mineral density decrease. In OP patients, the bone mineral density (BMD) decreases, the bone microstructure is destroyed, and the amount and type of protein are changed, which easily leads to fracture. It is extremely common in postmenopausal women and the elderly over 75 years old, and is an important factor that threatens the health of the elderly and reduces the quality of life. [0003] Osteoclasts (Osteoclast, OC) are differentiated from myeloid mononuclear cells of the hematopoietic stem cell line, and are the only physiological multinucleated giant cells in the human skeletal system that can absorb and remodel bone morpholog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61P19/10
CPCA61K31/7076
Inventor 窦策董世武曹震许建中
Owner ARMY MEDICAL UNIV
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