Pharmaceutical use of corydine derivative

A technology of cordidine base and medicine, applied in the field of malate salt and its pharmaceutical application, can solve the problems of adverse reactions, drug resistance, unsatisfactory drug treatment effect, etc., and achieve the effect of practical treatment activity

Inactive Publication Date: 2015-03-25
SHANGHAI YIZHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For now, although there are many kinds of drugs for the prevention and / or treatment of cervical cancer, these drugs are likely to cause multiple and severe adverse reactions, and some have developed drug resistance. still unsatisfactory

Method used

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  • Pharmaceutical use of corydine derivative
  • Pharmaceutical use of corydine derivative
  • Pharmaceutical use of corydine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] corydine malate

[0048] 3.41 g (0.01 mol) of the compound cordydine and 1.34 g (0.01 mol) of malic acid were dissolved in 100 ml of boiling ethanol. The hot solution was filtered through diatomaceous earth, then slowly cooled under gentle stirring, and stood for several hours in a temperature environment of 0-5°C, and the crystals of corydine malate were precipitated, and corydine malate was filtered out The crystals, washed with ethanol and dried under vacuum at 50°C, yielded 4.62 g of product.

Embodiment 2

[0050] corydine malate

[0051] The compound corydine malate 3.41 g and malic acid 1.34 g were stirred in 100 ml of refluxing ethanol until all the solids were dissolved. Add activated carbon, filter the hot solution through diatomaceous earth, and cool down to room temperature while stirring. Standing for several hours in a temperature environment of 0-5°C, the crystals of cordydine malate were precipitated, the crystals of cordydine malate were filtered out, washed with ethanol and dried under vacuum at 50°C to obtain 4.61 g product.

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PUM

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Abstract

The invention relates to corydine malate or a pharmaceutically acceptable solvate and an application thereof in preparation of medicaments for preventing and / or treating cervical cancer. The formula is as shown in the specification.

Description

field of invention [0001] The invention relates to the field of medicinal chemistry, in particular, the invention relates to a malate salt of a corydine derivative and a pharmaceutical use thereof. Background technique [0002] For now, although there are many kinds of drugs for the prevention and / or treatment of cervical cancer, these drugs are likely to cause multiple and severe adverse reactions, and some have developed drug resistance. Still unsatisfactory. Some active compounds for preventing and / or treating cervical cancer are described in the patent literature of China Invention Patent Granted Publication No. CN102302496 B. Contents of the invention [0003] The present invention discloses some new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds and pharmaceutical applications of these compounds and compositions. [0004] These compounds exhibit good water solubility stability and solid form stability. Som...

Claims

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Application Information

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IPC IPC(8): C07D221/18C07C59/245C07C51/41A61K31/473A61P35/00
CPCC07D221/18
Inventor 袁琦其他发明人请求不公开姓名
Owner SHANGHAI YIZHI MEDICAL TECH
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