Razor clam extractive used for promoting postpartum uterus contraction
A technology of uterine contraction and extract, applied in medical raw materials derived from molluscs, drug combinations, diseases, etc., can solve problems such as uterine contraction that has not been reported
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Embodiment 1
[0010] Embodiment 1, preparation has the razor clam extract that promotes postpartum uterine contraction:
[0011] (1) Appropriate amount of razor clam meat, homogenate;
[0012] (2) Add 1.5 times the volume of distilled water, and ultrasonically assist extraction at 30°C for 25 minutes;
[0013] (3) Stir and extract in a water bath at 30°C for 2 hours, centrifuge at 4000r / min for 5 minutes, take the supernatant, repeat the above operation for the residue, combine the filtrates, concentrate under reduced pressure to 1 / 3 volume, and freeze-dry to obtain the razor clam extract.
Embodiment 2
[0014] Example 2: Effect of razor clam extract on uterine contraction of isolated mice
[0015] Preparation of isolated mouse uteri: 2 days before the experiment, non-pregnant female mice were intraperitoneally injected with estradiol valerate every day to improve the sensitivity of the uterus to drugs; the mice were killed quickly by cervical dislocation, and the uteri were taken out by laparotomy to make about 1.0 cm strips of uterine smooth muscle. Put the uterus ligated with silk thread into a Maxwellian bath filled with 20ml, fix one end of the silk thread ligated to the specimen fixing hook in the bath, and connect the other end to the tension transducer, and give the uterus a load of 1g. After the uterine contraction is stable, the normal contraction curve is recorded. Add 1 drop of motherwort aqueous solution (as a control) and various concentrations of razor clam extract to each group, and after the uterine contraction is stable, use Biolap420E + The biological sig...
Embodiment 3
[0018] Embodiment 3: the preparation of razor clam extract tablet
[0019] prescription:
[0020] Razor clam extract 100mg
[0021] Lactose 100mg
[0022] Starch 295mg
[0024] Total 500mg
[0025] Weigh out the main ingredients respectively, mix the powder of razor clam extract through an 80-mesh sieve, lactose, and starch, use wet granulation, dry, mix with magnesium stearate after integration, and compress into tablets of 500 mg each agent.
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