Radioactive bracket for treating malignant tumor of digestive tract and preparation method thereof

A technology for malignant tumors and digestive tract, which is applied in the fields of biomedicine and polymer materials, and can solve problems such as the preparation method of radioactive scaffolds for malignant tumors of the digestive tract that have not yet been reported, and achieve low price, good application prospects, and simple preparation methods Effect

Inactive Publication Date: 2015-03-18
上海交通大学附属第一人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But so far, there is no report about the radioactive stent and its preparation method for the treatment of malignant tumors of the digestive tract.

Method used

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  • Radioactive bracket for treating malignant tumor of digestive tract and preparation method thereof
  • Radioactive bracket for treating malignant tumor of digestive tract and preparation method thereof
  • Radioactive bracket for treating malignant tumor of digestive tract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Such as figure 1 As shown, the radioactive stent for the treatment of malignant tumors of the digestive tract consists of the digestive tract stent 1, the inner layer 2, the outer layer 3 and the positioning sleeve 4; the digestive tract stent 1 is coated with the inner layer 2, and both sides of the inner layer 2 Set the position sleeve 4, the outer layer 3 wraps the inner layer 2 and the positioning sleeve 4;

[0037] The digestive tract stent 1 adopts the digestive tract stent in the prior art (commercially available);

[0038] The inner layer 2 is made of a mixture of silica gel and radioactive iodine-125; the outer layer 3 is silica gel for sealing iodine-125; and the positioning sleeve 4 is made of stainless steel.

Embodiment 2

[0040] figure 2 As shown, the steps of preparing a radioactive stent for treating malignant tumors of the digestive tract are as follows:

[0041] 1. Production process

[0042] (1) Production prescription

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Abstract

The invention belongs to the fields of biomedicine and high polymer material, and relates to a radioactive bracket for treating malignant tumor of digestive tract and the preparation method thereof. The bracket combines the radionuclide with the molecular surface of a degradable material, so as to produce radioactive biodegradation brackets of different concentrations for treating malignant tumor of digestive tract; the radioactive bracket for treating malignant tumor of digestive tract consists of a digestive tract bracket, an inner layer, an outer layer and positioning tube sleeves; the digestive tract bracket is coated with the inner layer, bilateral sides of the inner layer are provided with the positioning tube sleeves, and the outer layer wraps the inner layer and the positioning tube sleeves, wherein the inner layer is prepared by the mixture of a biocompatible high polymer material and a radioactive substance, the outer layer is a biocompatible high polymer material, and the positioning tube sleeves are made of stainless steel. The bracket can not only ensure the effective drainage of bile and pancreatic juice, but also treat the tumor with the locally precise radiotherapy effect; the bracket is safe, reliable, low cost, simple in preparation method, strong in practicability, and favorable application prospect.

Description

technical field [0001] The invention belongs to the fields of biomedicine and polymer materials, and relates to a radioactive support for treating digestive tract malignant tumors and a preparation method thereof. Background technique [0002] As a basic treatment method, radiopharmaceuticals have been widely used in clinical applications at home and abroad; especially brachytherapy for malignant tumors has the advantages of simple operation and good therapeutic effect, and its clinical application has shown broad prospects. [0003] At present, it is known that malignant tumor of digestive tract with stricture is a common clinical disease with a high incidence rate, and has always been a major problem that plagues the majority of medical workers. In a tertiary first-class hospital, about 200 to 300 patients are hospitalized each year due to malignant stenosis of the digestive tract and cancer of the digestive tract. Traditional treatment methods are generally ineffective, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61M36/04A61L31/10A61L31/08A61L31/16
Inventor 宛新建张伟星林丽洲肖静波李白文赵航
Owner 上海交通大学附属第一人民医院
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