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Yupingfeng powder modified compound as well as preparation method and application thereof

A technology of Scutellaria scutellariae Nepeta Yupingfeng powder for adding flavor and Yupingfeng powder, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of increased risk of infectious diseases and tumors, toxic and side effects, etc., and achieves good application Prospects, modernization and internationalization, active effect

Inactive Publication Date: 2015-03-11
NANJING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, cyclosporine A has no selective inhibitory effect on T cells in different states (activated and inactive) and all related immune responses mediated by T cells, so the normal immune function of the body borne by T cells is also affected. its inhibition
In fact, patients who take cyclosporine A for a long time can often observe the toxicity of the drug to the kidney and nervous system, and the risk of infectious diseases and tumors is increased
In addition, molecularly targeted immunosuppressants are new types of immunosuppressants developed in recent years mainly based on antibody preparations, but their suppression of immune responses is still non-selective and will cause serious side effects

Method used

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  • Yupingfeng powder modified compound as well as preparation method and application thereof
  • Yupingfeng powder modified compound as well as preparation method and application thereof

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Embodiment Construction

[0038] 1. Experimental method

[0039] BALB / c mice (normal group)

[0040] BALB / c pure line mice (purchased from Model Animal Center of Nanjing University), clean grade, weighing 18-22 g, half male and half male. Adaptive feeding. From the first day to the fifth day of the experiment, 0.2 ml of normal saline (0.9% NaCl) was administered to the stomach twice, with an interval of 6 hours between each time.

[0041] Construction of 2,4-Dinitrochlorobenzene-sensitized mouse model (DTH mice, pathological group / model group)

[0042] BALB / c pure line mice (purchased from Model Animal Center of Nanjing University), clean grade, weighing 18-22 g, half male and half male. Adaptive feeding for several days. The day before the experiment, the hair on the abdomen of the mouse was shaved, and 20ul of 1% 2,4-dinitrofluorobenzene (DNFB) (acetone: olive oil = 4:1) was applied for sensitization on the first morning. From the first day to the fifth day of the experiment, 0.2 ml of normal sa...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine formula compatibility, and in particular relates to a yupingfeng powder modified compound as well as a preparation method and application thereof. The yupingfeng powder modified compound can be prepared into scutellaria baicalensis yupingfeng powder modified compound when scutellaria baicalensis is added, is prepared into nepeta cataria yupingfeng powder modified compound when nepeta cataria is added, or is prepared into scutellaria baicalensis and nepeta cataria yupingfeng powder modified compound when scutellaria baicalensis and nepeta cataria are added. The research result shows that by adopting the yupingfeng powder modified compound, the auricle swelling degree of a DTH model mouse can be remarkably reduced, the spleen index is remarkably reduced, the content of IL-4 in mouse serum is remarkably increased, the content of IFN-gamma in mouse serum is remarkably reduced, the expression level of IL-6 in the spleen is remarkably reduced, particularly the inhibition functions of nepeta cataria YPF and scutellaria baicalensis and nepeta cataria YPF on the mouse auricle swelling degree are both higher than that of yupingfeng powder, the immunosuppressive action of scutellaria baicalensis YPF and scutellaria baicalensis and nepeta cataria YPF is higher than that of the yupingfeng powder, the ratio of IFN-gamma to IL-4 in nepeta cataria YPF is greatly superior to that of the yupingfeng powder, and the activation of nepeta cataria YPF in reducing the expression level of IL-6 in the spleen is also superior to that of the yupingfeng powder.

Description

1. Technical field [0001] The invention belongs to the technical field of prescription compatibility of traditional Chinese medicine, and in particular relates to a flavored compound prescription of Yupingfeng powder and its preparation method and application 2. Background technology [0002] A normal immune response is the main mechanism for the body to maintain its own balance and resist foreign aggression. Excessive immune responses can cause various autoimmune diseases, allergies, and various inflammatory reactions. Existing immunosuppressants aimed at suppressing excess immune response, such as glucocorticoids, cyclophosphamide, etc., often lead to overall suppression of immune response due to their lack of selectivity to cells and tissues, resulting in serious side effects. Cyclosporine A was the first drug developed specifically for immune-related diseases. However, cyclosporine A has no selective inhibitory effect on T cells in different states (activated and inacti...

Claims

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Application Information

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IPC IPC(8): A61K36/538A61K36/539A61P37/02A61P37/08A61P29/00A61P11/00A61P31/00A61P1/02A61P11/06A61P25/02A61P17/00A61P17/04A61P19/02A61P13/12A61P1/04A61P7/04A61P37/04A61P31/04A61P31/10
CPCA61K36/238A61K36/284A61K36/481A61K36/538A61K36/539A61K2236/53A61K2236/51A61K2236/331A61K2300/00Y02A50/30
Inventor 杨洁
Owner NANJING UNIV
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