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New application of type I collagen in preparation of medicament for treating and/or preventing psoriasis

A technology of collagen and collagen peptides, which is applied in the field of new application of type I collagen in the preparation of drugs for the treatment and/or prevention of psoriasis, which can solve the problems of large toxic and side effects and unsatisfactory curative effect, and achieve capillary repair , The effect of improving the phenomenon of hair loss

Inactive Publication Date: 2015-02-25
广西壮族自治区花红药业集团股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 5. Generally, it is severe in winter and light in summer, and often recurs
[0024] As psoriasis is currently understood to be a lifelong disease, there are currently no effective treatments
The clinical treatment mainly uses immunosuppressants, but most of these immunosuppressants have unsatisfactory curative effects and large toxic and side effects.
In the existing published literature, collagen is often used for cosmetic whitening, and so far there is no report on the use of type I collagen or type I collagen peptides for the treatment of psoriasis

Method used

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  • New application of type I collagen in preparation of medicament for treating and/or preventing psoriasis
  • New application of type I collagen in preparation of medicament for treating and/or preventing psoriasis
  • New application of type I collagen in preparation of medicament for treating and/or preventing psoriasis

Examples

Experimental program
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Effect test

Embodiment 1

[0057] Select chicken bones, wash and soak in 0.5% hydrochloric acid 5 times the weight of the chicken bones for 5 minutes, filter, rinse the chicken bones with clean water and crush them, add water 10 times the weight of the chicken bones, heat and extract for 1 hour, extract 3 times, filter The filtrates were combined and dried to obtain type I collagen with a purity of 30%.

Embodiment 2

[0059] Select pork bones, wash, drain, crush, add 5 times the weight of pork bones in 2% citric acid, soak for 5 minutes, filter, rinse with water until the pH is 6; add 1% NaCl solution and soak for 10 hours, The added NaCl solution is 12 times the weight of the pig bone; cool to 10°C, add trypsin, hydrolyze for 6 hours, after the hydrolysis, heat for 40 minutes to inactivate; obtain the hydrolyzate, concentrate the hydrolyzate and dry to obtain type I collagen Peptide, 78% pure.

Embodiment 3

[0061] Select fish bones, wash and soak in 2% lactic acid 10 times the weight of the fish bones for 120 minutes, filter, rinse the fish bones with clean water and crush them, add water 3 times the weight of the fish bones, heat and extract for 8 hours, extract once, filter The filtrate was filtered and dried to obtain type I collagen with a purity of 45%.

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Abstract

The invention relates to a new application of type I collagen, namely a new application of the type I collagen in preparation of a medicament for treating and / or preventing psoriasis, and in particular relates to the new application of the type I collagen in preparation of the medicament for treating and / or preventing psoriasis.

Description

technical field [0001] The present invention relates to a new application of type I collagen, that is, a new application in the preparation of medicines for the treatment and / or prevention of psoriasis, especially a new application of type I collagen peptides in the preparation of medicines for the treatment and / or prevention of psoriasis . Background technique [0002] Psoriasis is a chronic relapsing inflammatory skin disease induced by multiple factors and inherited by multiple genes, which seriously affects the quality of life of patients. According to reports, the principle of treatment is to control the disease, delay the development, relieve symptoms and reduce recurrence. Clinically, the drugs and methods for the treatment of psoriasis are divided into local treatment and systemic treatment. Local treatment includes the use of drugs such as glucocorticoids, anthranol, or photochemotherapy; systemic treatment includes the use of oral retinoic acid, methotrexate, cyc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P17/06
Inventor 韦飞燕刘计讪张艳华郭凤兰廖桂萍
Owner 广西壮族自治区花红药业集团股份公司
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