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Application of tylototriton verrucosus skin repair peptide cathelicidin-TV2

A technology for skin repair and wart newt, applied in skin diseases, medical preparations containing active ingredients, peptide/protein components, etc., can solve problems such as refractory consumption, affecting the patient's physical condition and quality of life, chronic delay, etc., to achieve Accelerate scar repair and reduce the effect of scar formation

Inactive Publication Date: 2015-01-21
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the disease is chronic and protracted, difficult to cure and consumes a lot, it has caused great psychological pressure to the patient and seriously affected the patient's physical condition and quality of life.

Method used

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  • Application of tylototriton verrucosus skin repair peptide cathelicidin-TV2
  • Application of tylototriton verrucosus skin repair peptide cathelicidin-TV2
  • Application of tylototriton verrucosus skin repair peptide cathelicidin-TV2

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Effects of skin repair peptide cathelicidin-TV2 on the proliferation of HUVEC cells.

[0027] Such as figure 1 As shown, at different concentrations of cathelicidin-TV2 at 1, 5, 10 and 20 μg / ml, compared with the control, the light absorption value at 570 nm was significantly increased gradually, and the concentration was 10, 20 μg / ml compared with the control. difference. It shows that cathelicidin-TV2 can promote the proliferation of HUVEC in vitro, and there is a significant concentration-dependent.

Embodiment 2

[0029] Effect of skin repair peptide cathelicidin-TV2 on red scrofula newt to NIH 3 T 3 effects on cell proliferation.

[0030] At different concentrations of Cathelicidin-TV2 at 1, 5, 10 and 20 μg / ml, compared with the control, the light absorption at 570 nm was slightly increased, and there were significant differences at the concentrations of 10 and 20 μg / ml compared with the control ( figure 2 ). Show that cathelicidin-TV2 can promote NIH 3 T 3 in vitro proliferation.

Embodiment 3

[0032] Effects of skin repair peptide cathelicidin-TV2 on the proliferation of HaCAT cells.

[0033] At different concentrations of cathelicidin-TV2 at 1, 5, 10 and 20 μg / ml, compared with the control, the light absorption value at 570 nm was gradually increased ( image 3 ). It shows that Cathelicidin-TV2 can promote the proliferation of HaCAT in vitro.

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Abstract

The invention belongs to the technical field of polypeptide drugs in biochemistry, and particularly relates to an application of tylototriton verrucosus skin repair peptide cathelicidin-TV2. The tylototriton verrucosus skin repair peptide cathelicidin-TV2 is obtained according to a conventional chemical synthesis method; the molecular weight of the tylototriton verrucosus skin repair peptide cathelicidin-TV2 is 1631.98Da, the isoelectric point is 11.02, and the primary structure of the complete sequence of the tylototriton verrucosus skin repair peptide cathelicidin-TV2 is RKCVRQNNKRVCK. The tylototriton verrucosus skin repair peptide cathelicidin-TV2 disclosed by the invention has the functions of reducing scar generated by skin trauma and accelerating the treatment or repair of scars, and can be applied to preparation of drugs for treating skin trauma, reducing scars and accelerating scar repair.

Description

Technical field: [0001] The invention belongs to the technical field of polypeptide drugs in biochemistry, and specifically relates to the application of cathelicidin-TV2, a skin repairing peptide of erythematous newt, in promoting skin repairing, reducing scars and accelerating scar repairing. Background technique: [0002] The skin is the first barrier for the body to contact with the outside world, the first line of defense for the body to avoid dehydration, injury, and infection, and the barrier to maintain the stability of the internal environment and prevent the invasion of microorganisms and chemical substances. Large-area skin defects and refractory skin ulcers caused by various acute and chronic injuries such as inflammation, ulcers, severe burns, trauma, tumor surgery, and congenital deformities will trigger many local and systemic reactions. Bacteria can easily invade and multiply after skin defects, which can cause water and electrolyte disorders in the body, sep...

Claims

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Application Information

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IPC IPC(8): A61K38/10A61P17/02
Inventor 赖仞容明强木丽仙
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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